TY - JOUR
T1 - G6PD deficiency in Latin America
T2 - Systematic review on prevalence and variants
AU - Monteiro, Wuelton M.
AU - Val, Fernando F.A.
AU - Siqueira, André M.
AU - Franca, Gabriel P.
AU - Sampaio, Vanderson S.
AU - Melo, Gisely C.
AU - Almeida, Anne C.G.
AU - Brito, Marcelo A.M.
AU - Peixoto, Henry M.
AU - Fuller, Douglas
AU - Bassat, Quique
AU - Romero, Gustavo A.S.
AU - Oliveira, Maria Regina F.
AU - Lacerda, Marcus Vinícius G.
PY - 2014/8
Y1 - 2014/8
N2 - Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.
AB - Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.
KW - Amerindians
KW - G6PD deficiency
KW - Haemolysis
KW - Malaria control
KW - Plasmodium vivax
KW - Primaquine
UR - http://www.scopus.com/inward/record.url?scp=84906731089&partnerID=8YFLogxK
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U2 - 10.1590/0074-0276140123
DO - 10.1590/0074-0276140123
M3 - Article
C2 - 25141282
AN - SCOPUS:84906731089
VL - 109
SP - 553
EP - 568
JO - Memorias do Instituto Oswaldo Cruz
JF - Memorias do Instituto Oswaldo Cruz
SN - 0074-0276
IS - 5
ER -