G6PD deficiency in Latin America: Systematic review on prevalence and variants

Wuelton M. Monteiro, Fernando F A Val, André M. Siqueira, Gabriel P. Franca, Vanderson S. Sampaio, Gisely C. Melo, Anne C G Almeida, Marcelo A M Brito, Henry M. Peixoto, Douglas Fuller, Quique Bassat, Gustavo A S Romero, Maria Regina F Oliveira, Marcus Vinícius G Lacerda

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.

Original languageEnglish (US)
Pages (from-to)553-568
Number of pages16
JournalMemorias do Instituto Oswaldo Cruz
Volume109
Issue number5
DOIs
StatePublished - 2014

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Glucosephosphate Dehydrogenase Deficiency
Latin America
Glucosephosphate Dehydrogenase
Primaquine
Malaria
Saint Lucia
Suriname
Trinidad and Tobago
Population
Uruguay
Bolivia
Ecuador
Jamaica
Plasmodium vivax
Cuba
Peru
Colombia
Manuscripts
Argentina
Bibliography

Keywords

  • Amerindians
  • G6PD deficiency
  • Haemolysis
  • Malaria control
  • Plasmodium vivax
  • Primaquine

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Monteiro, W. M., Val, F. F. A., Siqueira, A. M., Franca, G. P., Sampaio, V. S., Melo, G. C., ... Lacerda, M. V. G. (2014). G6PD deficiency in Latin America: Systematic review on prevalence and variants. Memorias do Instituto Oswaldo Cruz, 109(5), 553-568. https://doi.org/10.1590/0074-0276140123

G6PD deficiency in Latin America : Systematic review on prevalence and variants. / Monteiro, Wuelton M.; Val, Fernando F A; Siqueira, André M.; Franca, Gabriel P.; Sampaio, Vanderson S.; Melo, Gisely C.; Almeida, Anne C G; Brito, Marcelo A M; Peixoto, Henry M.; Fuller, Douglas; Bassat, Quique; Romero, Gustavo A S; Oliveira, Maria Regina F; Lacerda, Marcus Vinícius G.

In: Memorias do Instituto Oswaldo Cruz, Vol. 109, No. 5, 2014, p. 553-568.

Research output: Contribution to journalArticle

Monteiro, WM, Val, FFA, Siqueira, AM, Franca, GP, Sampaio, VS, Melo, GC, Almeida, ACG, Brito, MAM, Peixoto, HM, Fuller, D, Bassat, Q, Romero, GAS, Oliveira, MRF & Lacerda, MVG 2014, 'G6PD deficiency in Latin America: Systematic review on prevalence and variants', Memorias do Instituto Oswaldo Cruz, vol. 109, no. 5, pp. 553-568. https://doi.org/10.1590/0074-0276140123
Monteiro, Wuelton M. ; Val, Fernando F A ; Siqueira, André M. ; Franca, Gabriel P. ; Sampaio, Vanderson S. ; Melo, Gisely C. ; Almeida, Anne C G ; Brito, Marcelo A M ; Peixoto, Henry M. ; Fuller, Douglas ; Bassat, Quique ; Romero, Gustavo A S ; Oliveira, Maria Regina F ; Lacerda, Marcus Vinícius G. / G6PD deficiency in Latin America : Systematic review on prevalence and variants. In: Memorias do Instituto Oswaldo Cruz. 2014 ; Vol. 109, No. 5. pp. 553-568.
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