TY - JOUR
T1 - G-CSF and exenatide might be associated with increased long-term survival of allogeneic pancreatic islet grafts
AU - Zoso, Alessia
AU - Serafini, Paolo
AU - Lanzoni, Giacomo
AU - Peixoto, Eduardo
AU - Messinger, Shari
AU - Mantero, Alejandro
AU - Padilla-Téllez, Nathalia D.
AU - Baidal, David A.
AU - Alejandro, Rodolfo
AU - Ricordi, Camillo
AU - Inverardi, Luca
N1 - Funding Information:
This work was made possible thanks to the support of the staff of the Clinical Cell Transplant Program, cGMP Cell Processing Facility and the Miami Clinical and Translational Science Institute Clinical Translational Research Site. The authors want to thanks Dr. Juan Domín-guez-Bendala for the critical reading of the manuscript.
Funding Information:
Funding: This work was supported by the National Center for Research Resources: U42-RR16603 (CR), GCRC-M01RR16587 (CR); the National Institute of Diabetes and Digestive and Kidney Diseases: R01-DK55347 (CR), R01-DK25802 (LI), R01-DK25802 (CR); National Center for Advancing Translational: 1UL1TR000460 (CR); and the Juvenile Diabetes Research Foundation: 4-2000-946 (CR), 4-2004-361 (CR).
Publisher Copyright:
Copyright: © 2016 Zoso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - Background Allogeneic human islet transplantation is an effective therapy for the treatment of patients with Type 1 Diabetes (T1D). The low number of islet transplants performed worldwide and the different transplantation protocols used limit the identification of the most effective therapeutic options to improve the efficacy of this approach. Methods We present a retrospective analysis on the data collected from 44 patients with T1D who underwent islet transplantation at our institute between 2000 and 2007. Several variables were included: recipient demographics and immunological characteristics, donor and transplant characteristics, induction protocols, and additional medical treatment received. Immunosuppression was induced with anti-CD25 (Daclizumab), alone or in association with anti-tumor necrosis factor alpha (TNF-α) treatments (Etanercept or Infliximab), or with antiCD52 (Alemtuzumab) in association with anti-TNF-α treatments (Etanercept or Infliximab). Subsets of patients were treated with Filgrastim for moderate/severe neutropenia and/or Exenatide for post prandial hyperglycemia. Results The analysis performed indicates a negative association between graft survival (c-peptide level ≥ 0.3 ng/ml) and islet infusion volume, with the caveat that, the progressive reduction of infusion volumes over the years has been paralleled by improved immunosuppressive protocols. A positive association is instead suggested between graft survival and administration of Exenatide and Filgrastim, alone or in combination. Conclusion This retrospective analysis may be of assistance to further improve long-term outcomes of protocols for transplant of islets and other organs.
AB - Background Allogeneic human islet transplantation is an effective therapy for the treatment of patients with Type 1 Diabetes (T1D). The low number of islet transplants performed worldwide and the different transplantation protocols used limit the identification of the most effective therapeutic options to improve the efficacy of this approach. Methods We present a retrospective analysis on the data collected from 44 patients with T1D who underwent islet transplantation at our institute between 2000 and 2007. Several variables were included: recipient demographics and immunological characteristics, donor and transplant characteristics, induction protocols, and additional medical treatment received. Immunosuppression was induced with anti-CD25 (Daclizumab), alone or in association with anti-tumor necrosis factor alpha (TNF-α) treatments (Etanercept or Infliximab), or with antiCD52 (Alemtuzumab) in association with anti-TNF-α treatments (Etanercept or Infliximab). Subsets of patients were treated with Filgrastim for moderate/severe neutropenia and/or Exenatide for post prandial hyperglycemia. Results The analysis performed indicates a negative association between graft survival (c-peptide level ≥ 0.3 ng/ml) and islet infusion volume, with the caveat that, the progressive reduction of infusion volumes over the years has been paralleled by improved immunosuppressive protocols. A positive association is instead suggested between graft survival and administration of Exenatide and Filgrastim, alone or in combination. Conclusion This retrospective analysis may be of assistance to further improve long-term outcomes of protocols for transplant of islets and other organs.
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U2 - 10.1371/journal.pone.0157245
DO - 10.1371/journal.pone.0157245
M3 - Article
C2 - 27285580
AN - SCOPUS:85018870651
VL - 11
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 6
M1 - e0157245
ER -