Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders

Lucina Q. Uddin, Katherine H. Karlsgodt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Neurodevelopmental disorders are associated with atypical development and maturation of brain networks. A recent focus on human connectomics research and the growing popularity of open science initiatives has created the ideal climate in which to make real progress toward understanding the neurobiology of disorders affecting youth. Here we outline future directions for neuroscience researchers examining brain networks in neurodevelopmental disorders, highlighting gaps in the current literature. We emphasize the importance of leveraging large neuroimaging and phenotypic data sets recently made available to the research community, and we suggest specific novel methodological approaches, including analysis of brain dynamics and structural connectivity, that have the potential to produce the greatest clinical insight. Transdiagnostic approaches will also become increasingly necessary as the Research Domain Criteria framework put forth by the National Institute of Mental Health permeates scientific discourse. During this exciting era of big data and increased computational sophistication of analytic tools, the possibilities for significant advancement in understanding neurodevelopmental disorders are limitless.

Original languageEnglish (US)
Pages (from-to)483-497
Number of pages15
JournalJournal of Clinical Child and Adolescent Psychology
Issue number3
StatePublished - May 4 2018

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


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