Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.

P. Kastner; A. Perez; Y. Lutz; C. Rochette-Egly; M. P. Gaub; P. Chambon

Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.

Translated title of the contribution: Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia

P. Kastner, A. Perez, Y. Lutz, C. Rochette-Egly, M. P. Gaub, P. Chambon

Cell Biology & Anatomy

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.

Translated title of the contribution	Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia
Original language	French
Pages (from-to)	391-401
Number of pages	11
Journal	Comptes rendus des séances de la Société de biologie et de ses filiales
Volume	185
Issue number	6
State	Published - 1991

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Prot{\'e}ines de fusion entre PML et RAR-alpha dans les leuc{\'e}mies aigu{\"e}s {\`a} promy{\'e}locytes.",

abstract = "Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.",

author = "P. Kastner and A. Perez and Y. Lutz and C. Rochette-Egly and Gaub, {M. P.} and P. Chambon",

year = "1991",

language = "French",

volume = "185",

pages = "391--401",

journal = "Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales",

issn = "2105-0678",

publisher = "EDP Sciences",

number = "6",

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TY - JOUR

T1 - Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.

AU - Kastner, P.

AU - Perez, A.

AU - Lutz, Y.

AU - Rochette-Egly, C.

AU - Gaub, M. P.

AU - Chambon, P.

PY - 1991

Y1 - 1991

N2 - Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.

AB - Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.

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UR - http://www.scopus.com/inward/citedby.url?scp=0026285152&partnerID=8YFLogxK

M3 - Article

C2 - 1668321

AN - SCOPUS:0026285152

VL - 185

SP - 391

EP - 401

JO - Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales

JF - Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales

SN - 2105-0678

IS - 6

ER -

Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.

Abstract

ASJC Scopus subject areas

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