Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.

Translated title of the contribution: Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia

P. Kastner, A. Perez, Y. Lutz, C. Rochette-Egly, M. P. Gaub, P. Chambon

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.

Translated title of the contributionFusion proteins between PML and alpha-RAR in acute promyelocytic leukemia
Original languageFrench
Pages (from-to)391-401
Number of pages11
JournalComptes rendus des séances de la Société de biologie et de ses filiales
Volume185
Issue number6
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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