Abstract
Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.
| Translated title of the contribution | Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia |
|---|---|
| Original language | French |
| Pages (from-to) | 391-401 |
| Number of pages | 11 |
| Journal | Comptes rendus des séances de la Société de biologie et de ses filiales |
| Volume | 185 |
| Issue number | 6 |
| State | Published - 1991 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Kastner, P., Perez, A., Lutz, Y., Rochette-Egly, C., Gaub, M. P., & Chambon, P. (1991). Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes. Comptes rendus des séances de la Société de biologie et de ses filiales, 185(6), 391-401.