Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.
|Translated title of the contribution||Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia|
|Number of pages||11|
|Journal||Comptes rendus des séances de la Société de biologie et de ses filiales|
|State||Published - 1991|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)