Further studies on platelet serotonin transporter binding in depression

Charles Nemeroff, David L. Knight, Jean Franks, W. Edward Craighead, K. Ranga R Krishnan

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Objective: There is an impressive literature implicating abnormalities in serotonergic neural systems in depression. Many investigators, but not all, have reported low numbers of platelet and brain serotonin (5-HT) transporter sites in drug-free depressed patients. In the present study the authors sought to determine whether the low platelet 5-HT transporter binding in depressed patients is due to previous antidepressant drug exposure. In addition, the binding of both [3H]imipramine and the more specific ligand [3H]paroxetine to the platelet 5-HT transporter was compared in drug-free depressed patients and age- and sex-matched normal comparison subjects. Method: In the first experiment blood samples were obtained from 12 depressed patients who had never received antidepressant drugs and 12 normal comparison subjects, and platelet 5-HT transporter binding was measured by using [3H]imipramine. In the second experiment blood samples were obtained from 28 drug-free depressed patients and 28 age- and sex-matched comparison subjects, and platelet 5-HT transporter binding was assessed by using both [3H]imipramine and [3H]paroxetine. Results: In the first experiment the never-medicated depressed patients exhibited fewer platelet [3H]imipramine binding sites than did the comparison subjects. In the second experiment the drug-free depressed patients had fewer platelet binding sites for both [3H]imipramine and [3H]paroxetine than did the comparison subjects. Conclusions: The low number of platelet [3H]imipramine binding sites does not appear to be due to prior antidepressant drug exposure. The B(max) of platelet binding sites for both [3H]imipramine and [3H]paroxetine, ligands used to measure 5-HT transporter binding, is abnormally low in depressed patients.

Original languageEnglish
Pages (from-to)1623-1625
Number of pages3
JournalAmerican Journal of Psychiatry
Volume151
Issue number11
StatePublished - Nov 1 1994
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Imipramine
Serotonin
Blood Platelets
Paroxetine
Binding Sites
Antidepressive Agents
Platelet Count
Pharmaceutical Preparations
Ligands
Research Personnel
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Nemeroff, C., Knight, D. L., Franks, J., Craighead, W. E., & Krishnan, K. R. R. (1994). Further studies on platelet serotonin transporter binding in depression. American Journal of Psychiatry, 151(11), 1623-1625.

Further studies on platelet serotonin transporter binding in depression. / Nemeroff, Charles; Knight, David L.; Franks, Jean; Craighead, W. Edward; Krishnan, K. Ranga R.

In: American Journal of Psychiatry, Vol. 151, No. 11, 01.11.1994, p. 1623-1625.

Research output: Contribution to journalArticle

Nemeroff, C, Knight, DL, Franks, J, Craighead, WE & Krishnan, KRR 1994, 'Further studies on platelet serotonin transporter binding in depression', American Journal of Psychiatry, vol. 151, no. 11, pp. 1623-1625.
Nemeroff C, Knight DL, Franks J, Craighead WE, Krishnan KRR. Further studies on platelet serotonin transporter binding in depression. American Journal of Psychiatry. 1994 Nov 1;151(11):1623-1625.
Nemeroff, Charles ; Knight, David L. ; Franks, Jean ; Craighead, W. Edward ; Krishnan, K. Ranga R. / Further studies on platelet serotonin transporter binding in depression. In: American Journal of Psychiatry. 1994 ; Vol. 151, No. 11. pp. 1623-1625.
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