Further observations on the therapy of anovulatory infertility with synthetic luteinizing hormone releasing hormone

A. Zarate, E. S. Canales, J. Soria, A. Gonzalez, Andrew V Schally, A. J. Kastin

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Abstract

Synthetic LH RH was used in an attempt to induce ovulation and pregnancy in 42 women with suspected hypothalamic anovulation. Of the 42 women, ten ovulated and seven of them conceived; 24 of the 42 patients showed signs of follicular growth but did not ovulate. Monitoring follicular development by urinary estrogen excretion did not permit the assessment of the appropriate length of LH RH therapy. Injection of at least 200 μg LH RH on consecutive days induced ovulation most often. The i.m. administration of LH RH confirmed its efficacy in releasing LH and to a lesser extent, FSH. Patients who received LH RH daily for several days showed that the pituitary was capable of responding to repeated stimulus with LH secretion, and yet the release of FSH tended to be more variable. The results of the present study demonstrate that LH RH given i.m. induces ovulation, but it remains difficult to assess the correct dose of LH RH due to the individual varied response to treatment.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalFertility and Sterility
Volume25
Issue number1
StatePublished - Jan 1 1974
Externally publishedYes

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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