Abstract
The localization of the gene for the majority of cases of facioscapulohumeral muscular dystrophy is established as 4q35-qter (FSHD1A), although locus heterogeneity has been demonstrated with a minority of families unlinked to 4q. In FSHD1A, the disease is associated with a deletion of 3.3 kb repeats from a tandem repeat located near the as-yet-unidentified gene. This repeat cross-hybridizes with a telomeric region on 10q, making this cross-hybridizing region a feasible candidate gene for FSHD1B. We have tested the most telomeric marker on 10q (sAVA4) and excluded ∼17 cM on either side of this marker as harboring the FSHD1B gene.
Original language | English (US) |
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Pages (from-to) | 151-152 |
Number of pages | 2 |
Journal | Neurogenetics |
Volume | 1 |
Issue number | 2 |
DOIs | |
State | Published - 1997 |
Keywords
- Facioscapulohumeral muscular dystrophy
- Heterogeneity
- Linkage analysis
ASJC Scopus subject areas
- Genetics(clinical)
- Neuroscience(all)