Further exclusion of FSHD1B from the telomeric region of 10q

Marcy C. Speer, Margaret A. Pericak-Vance, Jeffrey M. Stajich, Jennifer Sarrica, Matthew Jordan, Allen D. Roses, Jeffery M. Vance, John R. Gilbert

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The localization of the gene for the majority of cases of facioscapulohumeral muscular dystrophy is established as 4q35-qter (FSHD1A), although locus heterogeneity has been demonstrated with a minority of families unlinked to 4q. In FSHD1A, the disease is associated with a deletion of 3.3 kb repeats from a tandem repeat located near the as-yet-unidentified gene. This repeat cross-hybridizes with a telomeric region on 10q, making this cross-hybridizing region a feasible candidate gene for FSHD1B. We have tested the most telomeric marker on 10q (sAVA4) and excluded ∼17 cM on either side of this marker as harboring the FSHD1B gene.

Original languageEnglish (US)
Pages (from-to)151-152
Number of pages2
Issue number2
StatePublished - 1997


  • Facioscapulohumeral muscular dystrophy
  • Heterogeneity
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)


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