Further exclusion of FSHD1B from the telomeric region of 10q

Marcy C. Speer, Margaret A. Pericak-Vance, Jeffrey M. Stajich, Jennifer Sarrica, Matthew Jordan, Allen D. Roses, Jeffery M. Vance, John R. Gilbert

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The localization of the gene for the majority of cases of facioscapulohumeral muscular dystrophy is established as 4q35-qter (FSHD1A), although locus heterogeneity has been demonstrated with a minority of families unlinked to 4q. In FSHD1A, the disease is associated with a deletion of 3.3 kb repeats from a tandem repeat located near the as-yet-unidentified gene. This repeat cross-hybridizes with a telomeric region on 10q, making this cross-hybridizing region a feasible candidate gene for FSHD1B. We have tested the most telomeric marker on 10q (sAVA4) and excluded ∼17 cM on either side of this marker as harboring the FSHD1B gene.

Original languageEnglish (US)
Pages (from-to)151-152
Number of pages2
JournalNeurogenetics
Volume1
Issue number2
DOIs
StatePublished - Jan 1 1997

Keywords

  • Facioscapulohumeral muscular dystrophy
  • Heterogeneity
  • Linkage analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Further exclusion of FSHD1B from the telomeric region of 10q'. Together they form a unique fingerprint.

  • Cite this

    Speer, M. C., Pericak-Vance, M. A., Stajich, J. M., Sarrica, J., Jordan, M., Roses, A. D., Vance, J. M., & Gilbert, J. R. (1997). Further exclusion of FSHD1B from the telomeric region of 10q. Neurogenetics, 1(2), 151-152. https://doi.org/10.1007/s100480050023