Further Characterization of Glycogen from Type‐IV Glycogen‐Storage Disease

Christiane Mercier, William J. Whelan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Glycogen from a male child suffering from type IV glycogenosis was debranched with bacterial isoamylase and fractionated on Sephadex G 50. The unit chains, set free by the isoamylase, emerged as a single peak, similar to that for normal human liver glycogen, but of higher average chain length. The pattern of the unit chains was distinctly different from that shown by amylopectin, which displays 2 populations of unit chains. It is thereby reaffirmed that, contrary to previous belief, type IV glycogen is not amylopectin like in structure, and the name 'amylopectinosis'' for this disease is inappropriate.

Original languageEnglish (US)
Pages (from-to)221-223
Number of pages3
JournalEuropean Journal of Biochemistry
Issue number1
StatePublished - Dec 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry


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