TY - JOUR
T1 - Fundulus as the premier teleost model in environmental biology
T2 - Opportunities for new insights using genomics
AU - Burnett, Karen G.
AU - Bain, Lisa J.
AU - Baldwin, William S.
AU - Callard, Gloria V.
AU - Cohen, Sarah
AU - Di Giulio, Richard T.
AU - Evans, David H.
AU - Gómez-Chiarri, Marta
AU - Hahn, Mark E.
AU - Hoover, Cindi A.
AU - Karchner, Sibel I.
AU - Katoh, Fumi
AU - MacLatchy, Deborah L.
AU - Marshall, William S.
AU - Meyer, Joel N.
AU - Nacci, Diane E.
AU - Oleksiak, Marjorie F.
AU - Rees, Bernard B.
AU - Singer, Thomas D.
AU - Stegeman, John J.
AU - Towle, David W.
AU - Van Veld, Peter A.
AU - Vogelbein, Wolfgang K.
AU - Whitehead, Andrew
AU - Winn, Richard N.
AU - Crawford, Douglas L.
N1 - Funding Information:
This material is based on work supported by grants from the National Science Foundation DBI-0420504 (LJB), OCE 0308777 (DLC, RNW, BBR), BES-0553523 (AW), IBN 0236494 (BBR), IOB-0519579 (DHE), IOB-0543860 (DWT), FSML-0533189 (SC); National Institute of Health NIEHS P42-ES007381(GVC, MEH), P42-ES10356 (RTD), ES011588 (MFO); and NCRR P20 RR-016463 (DWT); Natural Sciences and Engineering Research Council of Canada Discovery (DLM, TDS, WSM) and Collaborative Research and Development Programs (DLM); NOAA/National Sea Grant NA86RG0052 (LJB), NA16RG2273 (SIK, MEH,GVC, JJS); Environmental Protection Agency U91620701 (WSB), R82902201(SC) and EPA's Office of Research and Development (DEN). Special thanks go to the National Science Foundation for workshop funding under IOB-0539158 (KGB) and to the Hollings Marine Laboratory, Grice Marine Laboratory of the College of Charleston and the South Carolina Aquarium in Charleston, SC, for hosting the Fundulus Genomics Workshops in 2005 and 2006. We thank other participants in these workshops, including Tracy Andacht, Robert Chapman, John Colbourne, David Duvernell, Paul Gross, Josh Hamilton, Iris Knoebl, Paul Malchow, Jason Podrabsky, John Postlethwait, Robert Preston, Marc Salit, Joe Shaw, Rong-Lin Wang, Greg Warr and Ana Zimmerman for their ideas and comments in the development of this manuscript, and Chris Amemiya (Benaroya Research Institute) for supporting the creation of the Fundulus BAC library.
PY - 2007/12
Y1 - 2007/12
N2 - A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms.
AB - A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms.
KW - Ecological genomics
KW - Environmental genomics
KW - Evolutionary genomics
KW - Fundulus heteroclitus
KW - Physiological genomics
KW - Toxicogenomics
UR - http://www.scopus.com/inward/record.url?scp=35649026208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35649026208&partnerID=8YFLogxK
U2 - 10.1016/j.cbd.2007.09.001
DO - 10.1016/j.cbd.2007.09.001
M3 - Review article
AN - SCOPUS:35649026208
VL - 2
SP - 257
EP - 286
JO - Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
JF - Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
SN - 1744-117X
IS - 4
ER -