Functional T cells in athymic nude mice

S. Ikehara, Rajendra Pahwa, G. Fernandes, C. T. Hansen, R. A. Good

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

After passage of spleen cells from nu/nu mice over a nylon wool column, concanavalin A-responsive cells can be detected in the presence of 2-mercaptoethanol, and specific cytotoxic T lymphocytes can be generated without exposure to interleukin 2 (IL-2). The spleen cells of the nu/nu mice born of nu/nu parents and nursed by nu/nu mothers had significantly fewer Thy-1+ T cells and a lesser capacity to generate cytotoxic T lymphocytes that did the conventionally bred nu/nu mice. Nonetheless, such cells were clearly present. IL-2 may act to cause these post-thymic T cells to proliferate. Therefore, it seems inappropriate to consider IL-2 as an inducer of the differentiation of T cells in the absence of thymic influence on the basis of the capacity of IL-2 to induce the appearance of a T-lymphocyte population in nu/nu mice.

Original languageEnglish (US)
Pages (from-to)886-888
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number3 I
StatePublished - 1984
Externally publishedYes

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Nude Mice
Interleukin-2
T-Lymphocytes
Cytotoxic T-Lymphocytes
Spleen
Mercaptoethanol
Wool
Nylons
Concanavalin A
Population

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Ikehara, S., Pahwa, R., Fernandes, G., Hansen, C. T., & Good, R. A. (1984). Functional T cells in athymic nude mice. Proceedings of the National Academy of Sciences of the United States of America, 81(3 I), 886-888.

Functional T cells in athymic nude mice. / Ikehara, S.; Pahwa, Rajendra; Fernandes, G.; Hansen, C. T.; Good, R. A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, No. 3 I, 1984, p. 886-888.

Research output: Contribution to journalArticle

Ikehara, S, Pahwa, R, Fernandes, G, Hansen, CT & Good, RA 1984, 'Functional T cells in athymic nude mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 3 I, pp. 886-888.
Ikehara, S. ; Pahwa, Rajendra ; Fernandes, G. ; Hansen, C. T. ; Good, R. A. / Functional T cells in athymic nude mice. In: Proceedings of the National Academy of Sciences of the United States of America. 1984 ; Vol. 81, No. 3 I. pp. 886-888.
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