Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection

T. U. Vogel, T. M. Allen, J. D. Altman, D. I. Watkins

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

In an attempt to determine why high frequencies of circulating virus-specific CD8+ T cells are unable to control human immunodeficiency virus and simian immunodeficiency virus (SIV) replication, we assessed the functional nature of SIV-specific CD8+ lymphocytes. After vaccination and early after infection, nearly all tetramer-staining CD8+ cells produced gamma interferon in response to their specific stimulus. However, by 4 months postinfection with pathogenic SIVmac239, signs of functional impairment in the CD8+ T-cell compartment were detected which might prevent these T cells from efficiently controlling the infection during the chronic phase.

Original languageEnglish (US)
Pages (from-to)2458-2461
Number of pages4
JournalJournal of virology
Volume75
Issue number5
DOIs
StatePublished - Feb 22 2001

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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