Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques

Hong He, Pramod N. Nehete, Bharti Nehete, Eric Wieder, Guojun Yang, Stephanie Buchl, K. Jagannadha Sastry

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In HIV infection there is a paucity of literature about the degree of immune dysfunction to potentially correlate and/or predict disease progression relative to CD4+ T cells count or viral load. We assessed functional characteristics of memory T cells subsets as potential prognostic markers for changing viral loads and/or disease progression using the SHIV-infected rhesus macaque model. Relative to long-term non-progressors with low/undetectable viral loads, those with chronic plasma viremia, but clinically healthy, exhibited significantly lower numbers and functional impairment of CD4+ T cells, but not CD8+ T cells, in terms of IL-2 production by central memory subset in response to PMA and ionomycine (PMA+I) stimulation. Highly viremic animals showed impaired cytokine-production by all T cells subsets. These results suggest that functional impairment of CD4+ T cells in general, and of central memory subset in particular, may be a potential indicator/predictor of chronic infection with immune dysfunction, which could be assayed relatively easily using non-specific PMA+I stimulation.

Original languageEnglish
Article numbere19607
JournalPLoS One
Volume6
Issue number5
DOIs
StatePublished - May 18 2011

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T-cells
viral load
Macaca mulatta
Viral Load
T-lymphocytes
T-Lymphocytes
Data storage equipment
T-Lymphocyte Subsets
Disease Progression
disease course
Viremia
Virus Diseases
CD4 Lymphocyte Count
HIV Infections
Interleukin-2
viremia
HIV infections
Cytokines
interleukin-2
functional properties

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques. / He, Hong; Nehete, Pramod N.; Nehete, Bharti; Wieder, Eric; Yang, Guojun; Buchl, Stephanie; Sastry, K. Jagannadha.

In: PLoS One, Vol. 6, No. 5, e19607, 18.05.2011.

Research output: Contribution to journalArticle

He, Hong ; Nehete, Pramod N. ; Nehete, Bharti ; Wieder, Eric ; Yang, Guojun ; Buchl, Stephanie ; Sastry, K. Jagannadha. / Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques. In: PLoS One. 2011 ; Vol. 6, No. 5.
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