Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis

Tracy J. Doyle, Paul F. Dellaripa, Kerri Batra, Michelle L. Frits, Christine K. Iannaccone, Hiroto Hatabu, Mizuki Nishino, Michael E. Weinblatt, Dana Ascherman, George R. Washko, Gary M. Hunninghake, Augustine M K Choi, Nancy A. Shadick, Ivan O. Rosas

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

BACKGROUND: Approximately 10% of patients with rheumatoid arthritis (RA) have interstitial lung disease (ILD), and one-third have subclinical ILD on chest CT scan. In this study, we aimed to further characterize functional decrements in a spectrum of RA-associated ILD. M ETHODS: All subjects were enrolled in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS).The presence of interstitial lung abnormalities (ILAs) on clinically indicated chest CT scans was determined using a previously validated sequential reading method. Univariate and multivariate analyses were used to assess the association between degree of ILAs and physiologic, functional, and demographic variables of interest. R ESULTS: Of 1,145 BRASS subjects, 91 subjects (8%) were included in this study. Twelve had radiologically severe ILAs, 34 had ILAs, and 38 had no ILAs on CT scan. Subjects with radiologically severe ILAs were older ( P = .0037), had increased respiratory symptoms (cough, P = .027; dyspnea, P = .010), and more severe RA disease (rheumatoid factor, P = .018; total swollen joints, P = .046) compared with subjects with no ILAs. Participants also had a trend toward having an increased smoking history ( P = .16) and having lower FVC % predicted (77% vs 94%, P = .097) and diff usion capacity of carbon monoxide % predicted (52% vs 77%, P = .068). Similar but attenuated increases in respiratory symptoms, functional decrements, and RA disease severity were observed in subjects with ILAs compared with those with no ILAs. C ONCLUSIONS: We have shown that patients with RA have varying degrees of ILAs that are associated with a spectrum of functional and physiologic decrements. Our findings suggest that improved risk stratification and detection of ILAs will provide a therapeutic window that could improve RA-ILD outcomes.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalChest
Volume146
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Lung
Interstitial Lung Diseases
Thorax
Rheumatoid Factor
Carbon Monoxide
Cough
Dyspnea
Reading
Multivariate Analysis
Joints
Smoking
History
Demography

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Doyle, T. J., Dellaripa, P. F., Batra, K., Frits, M. L., Iannaccone, C. K., Hatabu, H., ... Rosas, I. O. (2014). Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. Chest, 146(1), 41-50. https://doi.org/10.1378/chest.13-1394

Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. / Doyle, Tracy J.; Dellaripa, Paul F.; Batra, Kerri; Frits, Michelle L.; Iannaccone, Christine K.; Hatabu, Hiroto; Nishino, Mizuki; Weinblatt, Michael E.; Ascherman, Dana; Washko, George R.; Hunninghake, Gary M.; Choi, Augustine M K; Shadick, Nancy A.; Rosas, Ivan O.

In: Chest, Vol. 146, No. 1, 01.01.2014, p. 41-50.

Research output: Contribution to journalArticle

Doyle, TJ, Dellaripa, PF, Batra, K, Frits, ML, Iannaccone, CK, Hatabu, H, Nishino, M, Weinblatt, ME, Ascherman, D, Washko, GR, Hunninghake, GM, Choi, AMK, Shadick, NA & Rosas, IO 2014, 'Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis', Chest, vol. 146, no. 1, pp. 41-50. https://doi.org/10.1378/chest.13-1394
Doyle TJ, Dellaripa PF, Batra K, Frits ML, Iannaccone CK, Hatabu H et al. Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. Chest. 2014 Jan 1;146(1):41-50. https://doi.org/10.1378/chest.13-1394
Doyle, Tracy J. ; Dellaripa, Paul F. ; Batra, Kerri ; Frits, Michelle L. ; Iannaccone, Christine K. ; Hatabu, Hiroto ; Nishino, Mizuki ; Weinblatt, Michael E. ; Ascherman, Dana ; Washko, George R. ; Hunninghake, Gary M. ; Choi, Augustine M K ; Shadick, Nancy A. ; Rosas, Ivan O. / Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. In: Chest. 2014 ; Vol. 146, No. 1. pp. 41-50.
@article{4b850cd51d534b3daedacf3c04ab37ac,
title = "Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis",
abstract = "BACKGROUND: Approximately 10{\%} of patients with rheumatoid arthritis (RA) have interstitial lung disease (ILD), and one-third have subclinical ILD on chest CT scan. In this study, we aimed to further characterize functional decrements in a spectrum of RA-associated ILD. M ETHODS: All subjects were enrolled in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS).The presence of interstitial lung abnormalities (ILAs) on clinically indicated chest CT scans was determined using a previously validated sequential reading method. Univariate and multivariate analyses were used to assess the association between degree of ILAs and physiologic, functional, and demographic variables of interest. R ESULTS: Of 1,145 BRASS subjects, 91 subjects (8{\%}) were included in this study. Twelve had radiologically severe ILAs, 34 had ILAs, and 38 had no ILAs on CT scan. Subjects with radiologically severe ILAs were older ( P = .0037), had increased respiratory symptoms (cough, P = .027; dyspnea, P = .010), and more severe RA disease (rheumatoid factor, P = .018; total swollen joints, P = .046) compared with subjects with no ILAs. Participants also had a trend toward having an increased smoking history ( P = .16) and having lower FVC {\%} predicted (77{\%} vs 94{\%}, P = .097) and diff usion capacity of carbon monoxide {\%} predicted (52{\%} vs 77{\%}, P = .068). Similar but attenuated increases in respiratory symptoms, functional decrements, and RA disease severity were observed in subjects with ILAs compared with those with no ILAs. C ONCLUSIONS: We have shown that patients with RA have varying degrees of ILAs that are associated with a spectrum of functional and physiologic decrements. Our findings suggest that improved risk stratification and detection of ILAs will provide a therapeutic window that could improve RA-ILD outcomes.",
author = "Doyle, {Tracy J.} and Dellaripa, {Paul F.} and Kerri Batra and Frits, {Michelle L.} and Iannaccone, {Christine K.} and Hiroto Hatabu and Mizuki Nishino and Weinblatt, {Michael E.} and Dana Ascherman and Washko, {George R.} and Hunninghake, {Gary M.} and Choi, {Augustine M K} and Shadick, {Nancy A.} and Rosas, {Ivan O.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1378/chest.13-1394",
language = "English",
volume = "146",
pages = "41--50",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

TY - JOUR

T1 - Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis

AU - Doyle, Tracy J.

AU - Dellaripa, Paul F.

AU - Batra, Kerri

AU - Frits, Michelle L.

AU - Iannaccone, Christine K.

AU - Hatabu, Hiroto

AU - Nishino, Mizuki

AU - Weinblatt, Michael E.

AU - Ascherman, Dana

AU - Washko, George R.

AU - Hunninghake, Gary M.

AU - Choi, Augustine M K

AU - Shadick, Nancy A.

AU - Rosas, Ivan O.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: Approximately 10% of patients with rheumatoid arthritis (RA) have interstitial lung disease (ILD), and one-third have subclinical ILD on chest CT scan. In this study, we aimed to further characterize functional decrements in a spectrum of RA-associated ILD. M ETHODS: All subjects were enrolled in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS).The presence of interstitial lung abnormalities (ILAs) on clinically indicated chest CT scans was determined using a previously validated sequential reading method. Univariate and multivariate analyses were used to assess the association between degree of ILAs and physiologic, functional, and demographic variables of interest. R ESULTS: Of 1,145 BRASS subjects, 91 subjects (8%) were included in this study. Twelve had radiologically severe ILAs, 34 had ILAs, and 38 had no ILAs on CT scan. Subjects with radiologically severe ILAs were older ( P = .0037), had increased respiratory symptoms (cough, P = .027; dyspnea, P = .010), and more severe RA disease (rheumatoid factor, P = .018; total swollen joints, P = .046) compared with subjects with no ILAs. Participants also had a trend toward having an increased smoking history ( P = .16) and having lower FVC % predicted (77% vs 94%, P = .097) and diff usion capacity of carbon monoxide % predicted (52% vs 77%, P = .068). Similar but attenuated increases in respiratory symptoms, functional decrements, and RA disease severity were observed in subjects with ILAs compared with those with no ILAs. C ONCLUSIONS: We have shown that patients with RA have varying degrees of ILAs that are associated with a spectrum of functional and physiologic decrements. Our findings suggest that improved risk stratification and detection of ILAs will provide a therapeutic window that could improve RA-ILD outcomes.

AB - BACKGROUND: Approximately 10% of patients with rheumatoid arthritis (RA) have interstitial lung disease (ILD), and one-third have subclinical ILD on chest CT scan. In this study, we aimed to further characterize functional decrements in a spectrum of RA-associated ILD. M ETHODS: All subjects were enrolled in the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS).The presence of interstitial lung abnormalities (ILAs) on clinically indicated chest CT scans was determined using a previously validated sequential reading method. Univariate and multivariate analyses were used to assess the association between degree of ILAs and physiologic, functional, and demographic variables of interest. R ESULTS: Of 1,145 BRASS subjects, 91 subjects (8%) were included in this study. Twelve had radiologically severe ILAs, 34 had ILAs, and 38 had no ILAs on CT scan. Subjects with radiologically severe ILAs were older ( P = .0037), had increased respiratory symptoms (cough, P = .027; dyspnea, P = .010), and more severe RA disease (rheumatoid factor, P = .018; total swollen joints, P = .046) compared with subjects with no ILAs. Participants also had a trend toward having an increased smoking history ( P = .16) and having lower FVC % predicted (77% vs 94%, P = .097) and diff usion capacity of carbon monoxide % predicted (52% vs 77%, P = .068). Similar but attenuated increases in respiratory symptoms, functional decrements, and RA disease severity were observed in subjects with ILAs compared with those with no ILAs. C ONCLUSIONS: We have shown that patients with RA have varying degrees of ILAs that are associated with a spectrum of functional and physiologic decrements. Our findings suggest that improved risk stratification and detection of ILAs will provide a therapeutic window that could improve RA-ILD outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84903836802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903836802&partnerID=8YFLogxK

U2 - 10.1378/chest.13-1394

DO - 10.1378/chest.13-1394

M3 - Article

VL - 146

SP - 41

EP - 50

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -