Functional dynamics of primate cortico-striatal networks during volitional movements

Lucas Santos, Ioan Opris, Robert Hampson, Dwayne W. Godwin, Greg Gerhardt, Samuel Deadwyler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The motor cortex and dorsal striatum (caudate nucleus and putamen) are key regions in motor processing but the interface between the cortex and striatum is not well understood. While dorsal striatum integrates information from multiple brain regions to shape motor learning and habit formation, the disruption of cortico-striatal circuits compromises the functionality of these circuits resulting in a multitude of neurologic disorders, including Parkinson's disease. To better understand the modulation of the cortico-striatal circuits we recorded simultaneously single neuron activity from four brain regions, primary motor, and sensory cortices, together with the rostral and caudal segments of the putamen in rhesus monkeys performing a visual motor task. Results show that spatial and temporal-task related firing relationships between these cortico-striatal circuit regions were modified by the independent administration of the two drugs (cocaine and baclofen). Spatial tuning and correlated firing of neurons from motor cortex and putamen were severely disrupted by cocaine and baclofen on correct trials, while the two drugs have dramatically decreased the functional connectivity of the motor cortical-striatal network. These findings provide insight into the modulation of cortical-striatal firing related to movement with implications for therapeutic approaches to Parkinson's disease and related disorders.

Original languageEnglish (US)
Article number27
JournalFrontiers in Systems Neuroscience
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 10 2014
Externally publishedYes

Fingerprint

Corpus Striatum
Primates
Putamen
Motor Cortex
Baclofen
Cocaine
Parkinson Disease
Neurons
Caudate Nucleus
Brain
Nervous System Diseases
Macaca mulatta
Pharmaceutical Preparations
Habits
Learning

Keywords

  • Mechanism of parkinson's disease
  • Motor cortex
  • Motorstriatal circuit
  • Simultaneous recording of sensorimotor striatal circuit with drug
  • Topographic of motor striatal circuit

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience

Cite this

Functional dynamics of primate cortico-striatal networks during volitional movements. / Santos, Lucas; Opris, Ioan; Hampson, Robert; Godwin, Dwayne W.; Gerhardt, Greg; Deadwyler, Samuel.

In: Frontiers in Systems Neuroscience, Vol. 8, No. MAR, 27, 10.03.2014.

Research output: Contribution to journalArticle

Santos, Lucas ; Opris, Ioan ; Hampson, Robert ; Godwin, Dwayne W. ; Gerhardt, Greg ; Deadwyler, Samuel. / Functional dynamics of primate cortico-striatal networks during volitional movements. In: Frontiers in Systems Neuroscience. 2014 ; Vol. 8, No. MAR.
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