Functional delay in lung maturation in fetuses of diabetic rabbits

Ilene Sosenko, E. E. Lawson, V. Demottaz, I. D. Frantz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Lung maturation was studied in fetuses of rabbits made diabetic with alloxan. Lung maturation was examined functionally with pressure-volume curves and by determining surfactant content of lung lavage on a surface balance, and biochemically by measuring disaturated phosphatidylcholine content (DSPC) and lecithin:sphingomyelin (L/S) ratio of lung lavage and DSPC content of lung tissue. Pressure-volume curves of 27.5-day fetuses of diabetic does demonstrated less deflation stability. Functional assessment of pulmonary lavage surfactant measured on a surface balance was less in diabetic fetuses at both 27.5 and 29.5 days of gestation. There were no differences in DSPC content or L/S of lung wash or DSPC in whole-lung tissue between diabetic and control fetuses. The discordance between surfactant function and concentrations of major surfactant phospholipids suggests that surfactant in fetuses of diabetic animals is qualitatively different from that in the normal fetus. These findings may explain why analysis of amniotic fluid phospholipid content sometimes fails to predict risk of respiratory distressed syndrome correctly in human diabetic pregnancies.

Original languageEnglish
Pages (from-to)643-647
Number of pages5
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume48
Issue number4
StatePublished - Jan 1 1980
Externally publishedYes

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Fetus
Rabbits
Surface-Active Agents
Lung
Bronchoalveolar Lavage
Sphingomyelins
Phospholipids
Pregnancy in Diabetics
Pulmonary Surfactants
Pressure
Alloxan
Lecithins
Amniotic Fluid
disaturated lecithin
Pregnancy

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Functional delay in lung maturation in fetuses of diabetic rabbits. / Sosenko, Ilene; Lawson, E. E.; Demottaz, V.; Frantz, I. D.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 48, No. 4, 01.01.1980, p. 643-647.

Research output: Contribution to journalArticle

Sosenko, Ilene ; Lawson, E. E. ; Demottaz, V. ; Frantz, I. D. / Functional delay in lung maturation in fetuses of diabetic rabbits. In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1980 ; Vol. 48, No. 4. pp. 643-647.
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