Functional connectivity of human striatum

A resting state fMRI study

A. Di Martino, A. Scheres, D. S. Margulies, A. M C Kelly, Lucina Q Uddin, Z. Shehzad, B. Biswal, J. R. Walters, F. X. Castellanos, M. P. Milham

Research output: Contribution to journalArticle

629 Citations (Scopus)

Abstract

Classically regarded as motor structures, the basal ganglia subserve a wide range of functions, including motor, cognitive, motivational, and emotional processes. Consistent with this broad-reaching involvement in brain function, basal ganglia dysfunction has been implicated in numerous neurological and psychiatric disorders. Despite recent advances in human neuroimaging, models of basal ganglia circuitry continue to rely primarily upon inference from animal studies. Here, we provide a comprehensive functional connectivity analysis of basal ganglia circuitry in humans through a functional magnetic resonance imaging examination during rest. Voxelwise regression analyses substantiated the hypothesized motor, cognitive, and affective divisions among striatal subregions, and provided in vivo evidence of a functional organization consistent with parallel and integrative loop models described in animals. Our findings also revealed subtler distinctions within striatal subregions not previously appreciated by task-based imaging approaches. For instance, the inferior ventral striatum is functionally connected with medial portions of orbitofrontal cortex, whereas a more superior ventral striatal seed is associated with medial and lateral portions. The ability to map multiple distinct striatal circuits in a single study in humans, as opposed to relying on meta-analyses of multiple studies, is a principal strength of resting state functional magnetic resonance imaging. This approach holds promise for studying basal ganglia dysfunction in clinical disorders.

Original languageEnglish (US)
Pages (from-to)2735-2747
Number of pages13
JournalCerebral Cortex
Volume18
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Corpus Striatum
Basal Ganglia
Magnetic Resonance Imaging
Prefrontal Cortex
Nervous System Diseases
Neuroimaging
Psychiatry
Meta-Analysis
Seeds
Regression Analysis
Brain

Keywords

  • Basal ganglia
  • Caudate
  • fMRI
  • Functional connectivity
  • Nucleus accumbens
  • Putamen
  • Resting state

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Di Martino, A., Scheres, A., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Shehzad, Z., ... Milham, M. P. (2008). Functional connectivity of human striatum: A resting state fMRI study. Cerebral Cortex, 18(12), 2735-2747. https://doi.org/10.1093/cercor/bhn041

Functional connectivity of human striatum : A resting state fMRI study. / Di Martino, A.; Scheres, A.; Margulies, D. S.; Kelly, A. M C; Uddin, Lucina Q; Shehzad, Z.; Biswal, B.; Walters, J. R.; Castellanos, F. X.; Milham, M. P.

In: Cerebral Cortex, Vol. 18, No. 12, 12.2008, p. 2735-2747.

Research output: Contribution to journalArticle

Di Martino, A, Scheres, A, Margulies, DS, Kelly, AMC, Uddin, LQ, Shehzad, Z, Biswal, B, Walters, JR, Castellanos, FX & Milham, MP 2008, 'Functional connectivity of human striatum: A resting state fMRI study', Cerebral Cortex, vol. 18, no. 12, pp. 2735-2747. https://doi.org/10.1093/cercor/bhn041
Di Martino A, Scheres A, Margulies DS, Kelly AMC, Uddin LQ, Shehzad Z et al. Functional connectivity of human striatum: A resting state fMRI study. Cerebral Cortex. 2008 Dec;18(12):2735-2747. https://doi.org/10.1093/cercor/bhn041
Di Martino, A. ; Scheres, A. ; Margulies, D. S. ; Kelly, A. M C ; Uddin, Lucina Q ; Shehzad, Z. ; Biswal, B. ; Walters, J. R. ; Castellanos, F. X. ; Milham, M. P. / Functional connectivity of human striatum : A resting state fMRI study. In: Cerebral Cortex. 2008 ; Vol. 18, No. 12. pp. 2735-2747.
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