@inproceedings{3547ee14e22242089df567dc5a039b13,
title = "Functional connectivity between Layer 2/3 and Layer 5 neurons in prefrontal cortex of nonhuman primates during a delayed match-to-sample task",
abstract = "The prefrontal cortex (PFC) has been postulated to play critical roles in cognitive control and the formation of long-term memories. To gain insights into the neurobiological mechanism of such high-order cognitive functions, it is important to understand the input-output transformational properties of the PFC micro-circuitry. In this study, we identify the functional connectivity between the Layer 2/3 (input) neurons and the Layer 5 (output) neurons using a previously developed generalized Volterra model (GVM). Input-output spike trains are recorded from the PFCs of nonhuman primates performing a memory-dependent delayed match-to-sample task with a customized conformal ceramic multi-electrode array. The GVM describes how the input spike trains are transformed into the output spike trains by the PFC micro-circuitry and represents the transformation in the form of Volterra kernels. Results show that Layer 2/3 neurons have strong and transient facilitatory effects on the firings of Layer 5 neurons. The magnitude and temporal range of the input-output nonlinear dynamics are strikingly different from those of the hippocampal CA3-CA1. This form of functional connectivity may have important implications to understanding the computational principle of the PFC.",
author = "Dong Song and Ioan Opris and Chan, {Rosa H.M.} and Marmarelis, {Vasilis Z.} and Hampson, {Robert E.} and Deadwyler, {Sam A.} and Berger, {Theodore W.}",
year = "2012",
month = dec,
day = "14",
doi = "10.1109/EMBC.2012.6346485",
language = "English (US)",
isbn = "9781424441198",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
pages = "2555--2558",
booktitle = "2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012",
note = "34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 ; Conference date: 28-08-2012 Through 01-09-2012",
}