Functional connectivity between Layer 2/3 and Layer 5 neurons in prefrontal cortex of nonhuman primates during a delayed match-to-sample task

Dong Song, Ioan Opris, Rosa H.M. Chan, Vasilis Z. Marmarelis, Robert E. Hampson, Sam A. Deadwyler, Theodore W. Berger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The prefrontal cortex (PFC) has been postulated to play critical roles in cognitive control and the formation of long-term memories. To gain insights into the neurobiological mechanism of such high-order cognitive functions, it is important to understand the input-output transformational properties of the PFC micro-circuitry. In this study, we identify the functional connectivity between the Layer 2/3 (input) neurons and the Layer 5 (output) neurons using a previously developed generalized Volterra model (GVM). Input-output spike trains are recorded from the PFCs of nonhuman primates performing a memory-dependent delayed match-to-sample task with a customized conformal ceramic multi-electrode array. The GVM describes how the input spike trains are transformed into the output spike trains by the PFC micro-circuitry and represents the transformation in the form of Volterra kernels. Results show that Layer 2/3 neurons have strong and transient facilitatory effects on the firings of Layer 5 neurons. The magnitude and temporal range of the input-output nonlinear dynamics are strikingly different from those of the hippocampal CA3-CA1. This form of functional connectivity may have important implications to understanding the computational principle of the PFC.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages2555-2558
Number of pages4
DOIs
StatePublished - Dec 14 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Song, D., Opris, I., Chan, R. H. M., Marmarelis, V. Z., Hampson, R. E., Deadwyler, S. A., & Berger, T. W. (2012). Functional connectivity between Layer 2/3 and Layer 5 neurons in prefrontal cortex of nonhuman primates during a delayed match-to-sample task. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 2555-2558). [6346485] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6346485