Functional brain imaging alterations in acne patients treated with isotretinoin

J. Douglas Bremner, Negar Fani, Ali Ashraf, John R. Votaw, Marijn E. Brummer, Thomas Cummins, Viola Vaccarino, Mark M. Goodman, Lai Reed, Sajid Siddiq, Charles Nemeroff

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Objective: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the brain; however, the effects of isotretinoin on brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients. Method: Brain functioning in adults was measured with [18F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). Results: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. Conclusions: This study suggests that isotretinoin treatment is associated with changes in brain functioning.

Original languageEnglish
Pages (from-to)983-991
Number of pages9
JournalAmerican Journal of Psychiatry
Volume162
Issue number5
DOIs
StatePublished - May 1 2005
Externally publishedYes

Fingerprint

Isotretinoin
Functional Neuroimaging
Acne Vulgaris
Brain
Depression
Anti-Bacterial Agents
Therapeutics
Fluorodeoxyglucose F18
Prefrontal Cortex
Positron-Emission Tomography
Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Functional brain imaging alterations in acne patients treated with isotretinoin. / Bremner, J. Douglas; Fani, Negar; Ashraf, Ali; Votaw, John R.; Brummer, Marijn E.; Cummins, Thomas; Vaccarino, Viola; Goodman, Mark M.; Reed, Lai; Siddiq, Sajid; Nemeroff, Charles.

In: American Journal of Psychiatry, Vol. 162, No. 5, 01.05.2005, p. 983-991.

Research output: Contribution to journalArticle

Bremner, JD, Fani, N, Ashraf, A, Votaw, JR, Brummer, ME, Cummins, T, Vaccarino, V, Goodman, MM, Reed, L, Siddiq, S & Nemeroff, C 2005, 'Functional brain imaging alterations in acne patients treated with isotretinoin', American Journal of Psychiatry, vol. 162, no. 5, pp. 983-991. https://doi.org/10.1176/appi.ajp.162.5.983
Bremner, J. Douglas ; Fani, Negar ; Ashraf, Ali ; Votaw, John R. ; Brummer, Marijn E. ; Cummins, Thomas ; Vaccarino, Viola ; Goodman, Mark M. ; Reed, Lai ; Siddiq, Sajid ; Nemeroff, Charles. / Functional brain imaging alterations in acne patients treated with isotretinoin. In: American Journal of Psychiatry. 2005 ; Vol. 162, No. 5. pp. 983-991.
@article{a90ec11c3f3b45d881a8b5414fd779d7,
title = "Functional brain imaging alterations in acne patients treated with isotretinoin",
abstract = "Objective: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the brain; however, the effects of isotretinoin on brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients. Method: Brain functioning in adults was measured with [18F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). Results: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21{\%} change versus 2{\%} change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. Conclusions: This study suggests that isotretinoin treatment is associated with changes in brain functioning.",
author = "Bremner, {J. Douglas} and Negar Fani and Ali Ashraf and Votaw, {John R.} and Brummer, {Marijn E.} and Thomas Cummins and Viola Vaccarino and Goodman, {Mark M.} and Lai Reed and Sajid Siddiq and Charles Nemeroff",
year = "2005",
month = "5",
day = "1",
doi = "10.1176/appi.ajp.162.5.983",
language = "English",
volume = "162",
pages = "983--991",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "5",

}

TY - JOUR

T1 - Functional brain imaging alterations in acne patients treated with isotretinoin

AU - Bremner, J. Douglas

AU - Fani, Negar

AU - Ashraf, Ali

AU - Votaw, John R.

AU - Brummer, Marijn E.

AU - Cummins, Thomas

AU - Vaccarino, Viola

AU - Goodman, Mark M.

AU - Reed, Lai

AU - Siddiq, Sajid

AU - Nemeroff, Charles

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Objective: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the brain; however, the effects of isotretinoin on brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients. Method: Brain functioning in adults was measured with [18F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). Results: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. Conclusions: This study suggests that isotretinoin treatment is associated with changes in brain functioning.

AB - Objective: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the brain; however, the effects of isotretinoin on brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients. Method: Brain functioning in adults was measured with [18F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). Results: Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. Conclusions: This study suggests that isotretinoin treatment is associated with changes in brain functioning.

UR - http://www.scopus.com/inward/record.url?scp=21044448352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21044448352&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.162.5.983

DO - 10.1176/appi.ajp.162.5.983

M3 - Article

C2 - 15863802

AN - SCOPUS:21044448352

VL - 162

SP - 983

EP - 991

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 5

ER -