Functional biomaterials: Design of novel biomaterials

S. E. Sakiyama-Elbert, J. A. Hubbell

Research output: Contribution to journalArticlepeer-review

195 Scopus citations


The field of biomaterials has recently been focused on the design of intelligent materials. Toward this goal, materials have been developed that can provide specific bioactive signals to control the biological environment around them during the process of materials integration and wound healing. In addition, materials have been developed that can respond to changes in their environment, such as a change in pH or cell-associated enzymatic activity. In designing such novel biomaterials, researchers have sought not merely to create bio-inert materials, but rather materials that can respond to the cellular environment around them to improve device integration and tissue regeneration.

Original languageEnglish (US)
Pages (from-to)183-201
Number of pages19
JournalAnnual Review of Materials Science
StatePublished - 2001


  • Cell adhesion
  • Drug delivery
  • Gene delivery

ASJC Scopus subject areas

  • Materials Science(all)


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