Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

Tadaaki Miyazaki, Atsuo Kawahara, Hodaka Fujii, Yoko Nakagawa, Yasuhiro Minami, Zhao Jun Liu, Isao Oishi, Olli Silvennoinen, Bruce A. Witthuhn, James N. Ihle, Tadatsugu Taniguchi

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464 Scopus citations

Abstract

The interleukin-2 receptor (IL-2R) consists of three subunits: the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, the last of which is also used in the receptors for IL-4, IL-7, and IL-9. Stimulation with IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases Jak1 and Jak3. Jak1 and Jak3 were found to be selectively associated with the 'serine-rich' region of IL-2Rβ and the carboxyl-terminal region of IL-2Rγ, respectively. Both regions were necessary for IL-2 signaling. Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling.

Original languageEnglish (US)
Pages (from-to)1045-1047
Number of pages3
JournalScience
Volume266
Issue number5187
DOIs
StatePublished - 1994

ASJC Scopus subject areas

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    Miyazaki, T., Kawahara, A., Fujii, H., Nakagawa, Y., Minami, Y., Liu, Z. J., Oishi, I., Silvennoinen, O., Witthuhn, B. A., Ihle, J. N., & Taniguchi, T. (1994). Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science, 266(5187), 1045-1047. https://doi.org/10.1126/science.7973659