Function of JAKs and STATs in lymphocytes: Bench to bedside

Alejandro Villarino, Xiang Ping Yang, Kiyoshi Hirahara, Yuka Kanno, John J. O'Shea, Arian Laurence

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There are four members of Janus Kinase family (JAK-1, -2, -3 and TYK2) and seven members of STAT family (STAT-1, -2, -3, -4, -5a, -5b and -6) in the mammalian genome, each with unique functions in immune cells. Consistent with studies in mice, genetic evidence in humans has strongly linked the JAK/STAT pathway to primary immunodeficiencies, infection, autoimmunity and cancers. The following chapter will discuss the key role played by JAKs and STATs in the lymphocytes, with special emphasis on helper T cells, which are not only critical mediators of pathogenic inflammation, but also an outstanding model system for investigating JAK/STAT biology. Recent conceptual and technological advances will be highlighted, particularly those relating to human disease and the generation of JAK/STAT based therapeutics.

Original languageEnglish (US)
Title of host publicationJak-Stat Signaling
Subtitle of host publicationFrom Basics to Disease
PublisherSpringer-Verlag Wien
Pages205-237
Number of pages33
Volume9783709108918
ISBN (Electronic)9783709108918
ISBN (Print)370910890X, 9783709108901
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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