Fulminant or subfulminant non-A, non-B viral hepatitis

The role of hepatitis C and E viruses

T. Jake Liang, Lennox J Jeffers, Rajender K. Reddy, Marcelo O. Silva, Hugo Cheinquer, Andres Findor, Maria De Medina, Patrice O. Yarbough, Gregory R. Reyes, Eugene R Schiff

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Background: Although non-A, non-B (NANB) viral hepatitis has been implicated as an etiology of fulminant hepatitis, hepatitis C virus (HCV) has not been shown to result in acute hepatic failure and hepatitis E virus (HEV) has predominantly been associated with fulminant hepatitis among pregnant women. Methods: Using polymerase chain reaction to detect HCV and HEV genomes, four-antigen radioimmunoblot assay (4-RIBA) to measure anti-HCV antibodies, and enzyme-linked immunosorbent assay (ELISA) to detect anti-HEV immunoglobulin M (IgM) antibodies, 17 patients with sporadic fulminant or subfulminant hepatitis of presumed NANB viral etiology were studied. Results: The diagnosis of acute NANB viral hepatitis was made based on clinical information, serological tests, biochemical profiles, and pathological features. All 17 patients were negative for anti-HEV IgM antibodies and HEV RNA in either serum and/or liver. HCV RNAs were detected in 2 patients although anti-HCV antibodies were negative in all of them. Conclusions: It is shown that HCV is infrequently associated with and HEV is not an identifiable cause of presumed NANB fulminant or subfulminant hepatitis in this patient population. Although further studies will be required for identification of the causative agent, it is possible that another agent is responsible for the occurrence of sporadic NANB fulminant or subfulminant hepatitis.

Original languageEnglish
Pages (from-to)556-562
Number of pages7
JournalGastroenterology
Volume104
Issue number2
StatePublished - Jan 1 1993

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Hepatitis E virus
Hepacivirus
Hepatitis
Hepatitis C Antibodies
Immunoglobulin E
Immunoglobulin M
RNA
Acute Liver Failure
Antibodies
Serologic Tests
Pregnant Women
Enzyme-Linked Immunosorbent Assay
Genome
Antigens
Polymerase Chain Reaction
Liver
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Liang, T. J., Jeffers, L. J., Reddy, R. K., Silva, M. O., Cheinquer, H., Findor, A., ... Schiff, E. R. (1993). Fulminant or subfulminant non-A, non-B viral hepatitis: The role of hepatitis C and E viruses. Gastroenterology, 104(2), 556-562.

Fulminant or subfulminant non-A, non-B viral hepatitis : The role of hepatitis C and E viruses. / Liang, T. Jake; Jeffers, Lennox J; Reddy, Rajender K.; Silva, Marcelo O.; Cheinquer, Hugo; Findor, Andres; De Medina, Maria; Yarbough, Patrice O.; Reyes, Gregory R.; Schiff, Eugene R.

In: Gastroenterology, Vol. 104, No. 2, 01.01.1993, p. 556-562.

Research output: Contribution to journalArticle

Liang, TJ, Jeffers, LJ, Reddy, RK, Silva, MO, Cheinquer, H, Findor, A, De Medina, M, Yarbough, PO, Reyes, GR & Schiff, ER 1993, 'Fulminant or subfulminant non-A, non-B viral hepatitis: The role of hepatitis C and E viruses', Gastroenterology, vol. 104, no. 2, pp. 556-562.
Liang TJ, Jeffers LJ, Reddy RK, Silva MO, Cheinquer H, Findor A et al. Fulminant or subfulminant non-A, non-B viral hepatitis: The role of hepatitis C and E viruses. Gastroenterology. 1993 Jan 1;104(2):556-562.
Liang, T. Jake ; Jeffers, Lennox J ; Reddy, Rajender K. ; Silva, Marcelo O. ; Cheinquer, Hugo ; Findor, Andres ; De Medina, Maria ; Yarbough, Patrice O. ; Reyes, Gregory R. ; Schiff, Eugene R. / Fulminant or subfulminant non-A, non-B viral hepatitis : The role of hepatitis C and E viruses. In: Gastroenterology. 1993 ; Vol. 104, No. 2. pp. 556-562.
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AU - Silva, Marcelo O.

AU - Cheinquer, Hugo

AU - Findor, Andres

AU - De Medina, Maria

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