Fulminant liver failure and pancreatitis associated with the use of sulfamethoxazole-trimethoprim

J. J. Alberti-Flor, M. E. Hernandez, J. P. Ferrer, S. Howell, L. Jeffers

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

We report the case of a 26-yr-old patient with fulminant liver failure and acute hemorrhagic pancreatitis secondary to the use of trimethoprim-sulfamethoxazole (Bactrim DS). Our patient presented with skin rash and decreased C3 and C4 levels, which we believed was due to a hypersensitive reaction secondary to the sulfonamide component (sulfamethoxazole). To our knowledge, this is the first case reported in which sulfamethoxazole-trimethoprim has been implicated as a cause of fulminant liver failure and acute hemorrhagic pancreatitis simultaneously, and emphasizes the need of discontinuing this medication as soon as there is evidence of liver and pancreatic dysfunction.

Original languageEnglish (US)
Pages (from-to)1577-1579
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume84
Issue number12
StatePublished - Dec 1 1989

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Fulminant liver failure and pancreatitis associated with the use of sulfamethoxazole-trimethoprim'. Together they form a unique fingerprint.

  • Cite this

    Alberti-Flor, J. J., Hernandez, M. E., Ferrer, J. P., Howell, S., & Jeffers, L. (1989). Fulminant liver failure and pancreatitis associated with the use of sulfamethoxazole-trimethoprim. American Journal of Gastroenterology, 84(12), 1577-1579.