Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult

L. Abbo, M. L. Alcaide, J. R. Pano, P. G. Robinson, R. E. Campo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalTransplant Infectious Disease
Issue number4
StatePublished - Dec 1 2007


  • Fulminant liver failure
  • Hepatitis
  • HSV
  • Immunocompetent

ASJC Scopus subject areas

  • Transplantation
  • Microbiology (medical)
  • Immunology


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