Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult

Lilian Abbo, Maria L Alcaide, J. R. Pano, P. G. Robinson, Rafael E Campo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalTransplant Infectious Disease
Volume9
Issue number4
DOIs
StatePublished - Dec 1 2007

Fingerprint

Human Herpesvirus 2
Simplexvirus
Hepatitis
Acute Liver Failure
Virus Diseases
Sensory Ganglia
Liver
Frozen Sections
Immunocompromised Host
Needle Biopsy
Septic Shock
Infection
Autopsy
Cell Culture Techniques
Immunohistochemistry
Pediatrics
Viruses

Keywords

  • Fulminant liver failure
  • Hepatitis
  • HSV
  • Immunocompetent

ASJC Scopus subject areas

  • Transplantation
  • Microbiology (medical)
  • Immunology

Cite this

Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult. / Abbo, Lilian; Alcaide, Maria L; Pano, J. R.; Robinson, P. G.; Campo, Rafael E.

In: Transplant Infectious Disease, Vol. 9, No. 4, 01.12.2007, p. 323-326.

Research output: Contribution to journalArticle

Abbo, Lilian ; Alcaide, Maria L ; Pano, J. R. ; Robinson, P. G. ; Campo, Rafael E. / Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult. In: Transplant Infectious Disease. 2007 ; Vol. 9, No. 4. pp. 323-326.
@article{eca036d3fbdd41c88b092b6c8060b2fb,
title = "Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult",
abstract = "Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.",
keywords = "Fulminant liver failure, Hepatitis, HSV, Immunocompetent",
author = "Lilian Abbo and Alcaide, {Maria L} and Pano, {J. R.} and Robinson, {P. G.} and Campo, {Rafael E}",
year = "2007",
month = "12",
day = "1",
doi = "10.1111/j.1399-3062.2007.00207.x",
language = "English",
volume = "9",
pages = "323--326",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult

AU - Abbo, Lilian

AU - Alcaide, Maria L

AU - Pano, J. R.

AU - Robinson, P. G.

AU - Campo, Rafael E

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.

AB - Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.

KW - Fulminant liver failure

KW - Hepatitis

KW - HSV

KW - Immunocompetent

UR - http://www.scopus.com/inward/record.url?scp=35848954518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35848954518&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3062.2007.00207.x

DO - 10.1111/j.1399-3062.2007.00207.x

M3 - Article

C2 - 17605748

AN - SCOPUS:35848954518

VL - 9

SP - 323

EP - 326

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 4

ER -