Abstract
Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.
| Original language | English |
|---|---|
| Pages (from-to) | 323-326 |
| Number of pages | 4 |
| Journal | Transplant Infectious Disease |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2007 |
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Keywords
- Fulminant liver failure
- Hepatitis
- HSV
- Immunocompetent
ASJC Scopus subject areas
- Transplantation
- Microbiology (medical)
- Immunology
Cite this
Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult. / Abbo, Lilian; Alcaide, Maria L; Pano, J. R.; Robinson, P. G.; Campo, Rafael E.
In: Transplant Infectious Disease, Vol. 9, No. 4, 01.12.2007, p. 323-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult
AU - Abbo, Lilian
AU - Alcaide, Maria L
AU - Pano, J. R.
AU - Robinson, P. G.
AU - Campo, Rafael E
PY - 2007/12/1
Y1 - 2007/12/1
N2 - Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.
AB - Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.
KW - Fulminant liver failure
KW - Hepatitis
KW - HSV
KW - Immunocompetent
UR - http://www.scopus.com/inward/record.url?scp=35848954518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35848954518&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3062.2007.00207.x
DO - 10.1111/j.1399-3062.2007.00207.x
M3 - Article
C2 - 17605748
AN - SCOPUS:35848954518
VL - 9
SP - 323
EP - 326
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
IS - 4
ER -