Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer

Michael Frumovitz, Brian Slomovitz, Diljeet K. Singh, Russell R. Broaddus, Jacki Abrams, Charlotte C. Sun, Michael Bevers, Diane C. Bodurka

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Background Many gynecologic oncologists use intraoperative frozen section (IFS) assessment of histologic grade and depth of myometrial invasion (DOI) as predictors of final grade and stage in women with endometrial cancer. This clinical decision method has never been critically examined. Study design We retrospectively reviewed charts of patients with a preoperative diagnosis of uterine endometrioid adenocarcinoma and an intraoperative frozen section assessment of histologic grade and depth of myometrial invasion. Intraoperative predictors combining intraoperative frozen section assessment of histologic grade and depth of myometrial invasion were established and compared with final grade and surgical stage. We then modeled the risks of pelvic and paraaortic lymph node metastases for each predictor. Results There were 129 patients who met inclusion criteria. Thirty-six patients had the IAG1 predictor; 17 (47%) were stage IAG1 on final pathology. Ten patients had the IAG2 predictor; 3 (30%) were stage IAG2 on final pathology. Thirty-four patients had the IBG1 predictor; 18 (53%) were stage IBG1 on final pathology. Forty-nine patients had the IBG2 predictor; 34 (69%) were stage IBG2 on final pathology. Our decision models predict that the IAG1 predictor has a 1% risk of paraaortic and a 2% risk of pelvic lymph node metastases. The IAG2 and IBG1 predictors have a 2% risk of paraaortic and a 4% risk of pelvic lymph node metastases. The IBG2 predictor has a 2% risk of paraaortic and a 6% risk of pelvic lymph node metastases. Conclusions The combination of intraoperative frozen section analysis for histologic grade and depth of myometrial invasion does not correlate well with final pathologic grade and stage. Data from our models suggest a significant risk of lymph node spread even for patients with seemingly low-risk disease. Until better markers of lymphatic spread exist, we recommend complete surgical staging of all patients with endometrial cancer.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalJournal of the American College of Surgeons
Volume199
Issue number3
DOIs
StatePublished - Sep 2004
Externally publishedYes

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Uterine Neoplasms
Frozen Sections
Lymph Nodes
Pathology
Neoplasm Metastasis
Endometrial Neoplasms
Endometrioid Carcinoma

ASJC Scopus subject areas

  • Surgery

Cite this

Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer. / Frumovitz, Michael; Slomovitz, Brian; Singh, Diljeet K.; Broaddus, Russell R.; Abrams, Jacki; Sun, Charlotte C.; Bevers, Michael; Bodurka, Diane C.

In: Journal of the American College of Surgeons, Vol. 199, No. 3, 09.2004, p. 388-393.

Research output: Contribution to journalArticle

Frumovitz, Michael ; Slomovitz, Brian ; Singh, Diljeet K. ; Broaddus, Russell R. ; Abrams, Jacki ; Sun, Charlotte C. ; Bevers, Michael ; Bodurka, Diane C. / Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer. In: Journal of the American College of Surgeons. 2004 ; Vol. 199, No. 3. pp. 388-393.
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title = "Frozen section analyses as predictors of lymphatic spread in patients with early-stage uterine cancer",
abstract = "Background Many gynecologic oncologists use intraoperative frozen section (IFS) assessment of histologic grade and depth of myometrial invasion (DOI) as predictors of final grade and stage in women with endometrial cancer. This clinical decision method has never been critically examined. Study design We retrospectively reviewed charts of patients with a preoperative diagnosis of uterine endometrioid adenocarcinoma and an intraoperative frozen section assessment of histologic grade and depth of myometrial invasion. Intraoperative predictors combining intraoperative frozen section assessment of histologic grade and depth of myometrial invasion were established and compared with final grade and surgical stage. We then modeled the risks of pelvic and paraaortic lymph node metastases for each predictor. Results There were 129 patients who met inclusion criteria. Thirty-six patients had the IAG1 predictor; 17 (47{\%}) were stage IAG1 on final pathology. Ten patients had the IAG2 predictor; 3 (30{\%}) were stage IAG2 on final pathology. Thirty-four patients had the IBG1 predictor; 18 (53{\%}) were stage IBG1 on final pathology. Forty-nine patients had the IBG2 predictor; 34 (69{\%}) were stage IBG2 on final pathology. Our decision models predict that the IAG1 predictor has a 1{\%} risk of paraaortic and a 2{\%} risk of pelvic lymph node metastases. The IAG2 and IBG1 predictors have a 2{\%} risk of paraaortic and a 4{\%} risk of pelvic lymph node metastases. The IBG2 predictor has a 2{\%} risk of paraaortic and a 6{\%} risk of pelvic lymph node metastases. Conclusions The combination of intraoperative frozen section analysis for histologic grade and depth of myometrial invasion does not correlate well with final pathologic grade and stage. Data from our models suggest a significant risk of lymph node spread even for patients with seemingly low-risk disease. Until better markers of lymphatic spread exist, we recommend complete surgical staging of all patients with endometrial cancer.",
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AU - Sun, Charlotte C.

AU - Bevers, Michael

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N2 - Background Many gynecologic oncologists use intraoperative frozen section (IFS) assessment of histologic grade and depth of myometrial invasion (DOI) as predictors of final grade and stage in women with endometrial cancer. This clinical decision method has never been critically examined. Study design We retrospectively reviewed charts of patients with a preoperative diagnosis of uterine endometrioid adenocarcinoma and an intraoperative frozen section assessment of histologic grade and depth of myometrial invasion. Intraoperative predictors combining intraoperative frozen section assessment of histologic grade and depth of myometrial invasion were established and compared with final grade and surgical stage. We then modeled the risks of pelvic and paraaortic lymph node metastases for each predictor. Results There were 129 patients who met inclusion criteria. Thirty-six patients had the IAG1 predictor; 17 (47%) were stage IAG1 on final pathology. Ten patients had the IAG2 predictor; 3 (30%) were stage IAG2 on final pathology. Thirty-four patients had the IBG1 predictor; 18 (53%) were stage IBG1 on final pathology. Forty-nine patients had the IBG2 predictor; 34 (69%) were stage IBG2 on final pathology. Our decision models predict that the IAG1 predictor has a 1% risk of paraaortic and a 2% risk of pelvic lymph node metastases. The IAG2 and IBG1 predictors have a 2% risk of paraaortic and a 4% risk of pelvic lymph node metastases. The IBG2 predictor has a 2% risk of paraaortic and a 6% risk of pelvic lymph node metastases. Conclusions The combination of intraoperative frozen section analysis for histologic grade and depth of myometrial invasion does not correlate well with final pathologic grade and stage. Data from our models suggest a significant risk of lymph node spread even for patients with seemingly low-risk disease. Until better markers of lymphatic spread exist, we recommend complete surgical staging of all patients with endometrial cancer.

AB - Background Many gynecologic oncologists use intraoperative frozen section (IFS) assessment of histologic grade and depth of myometrial invasion (DOI) as predictors of final grade and stage in women with endometrial cancer. This clinical decision method has never been critically examined. Study design We retrospectively reviewed charts of patients with a preoperative diagnosis of uterine endometrioid adenocarcinoma and an intraoperative frozen section assessment of histologic grade and depth of myometrial invasion. Intraoperative predictors combining intraoperative frozen section assessment of histologic grade and depth of myometrial invasion were established and compared with final grade and surgical stage. We then modeled the risks of pelvic and paraaortic lymph node metastases for each predictor. Results There were 129 patients who met inclusion criteria. Thirty-six patients had the IAG1 predictor; 17 (47%) were stage IAG1 on final pathology. Ten patients had the IAG2 predictor; 3 (30%) were stage IAG2 on final pathology. Thirty-four patients had the IBG1 predictor; 18 (53%) were stage IBG1 on final pathology. Forty-nine patients had the IBG2 predictor; 34 (69%) were stage IBG2 on final pathology. Our decision models predict that the IAG1 predictor has a 1% risk of paraaortic and a 2% risk of pelvic lymph node metastases. The IAG2 and IBG1 predictors have a 2% risk of paraaortic and a 4% risk of pelvic lymph node metastases. The IBG2 predictor has a 2% risk of paraaortic and a 6% risk of pelvic lymph node metastases. Conclusions The combination of intraoperative frozen section analysis for histologic grade and depth of myometrial invasion does not correlate well with final pathologic grade and stage. Data from our models suggest a significant risk of lymph node spread even for patients with seemingly low-risk disease. Until better markers of lymphatic spread exist, we recommend complete surgical staging of all patients with endometrial cancer.

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