Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

Kenneth M. Heilman, Dawn Bowers, Robert T. Watson, Arthur Day, Edward Valenstein, Edward Hammond, Ranjan Duara

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.

Original languageEnglish
Pages (from-to)161-169
Number of pages9
JournalNeuropsychologia
Volume28
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Amnesia
Anterior Thalamic Nuclei
Fluorodeoxyglucose F18
Temporal Lobe
Thalamus
Positron-Emission Tomography

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Heilman, K. M., Bowers, D., Watson, R. T., Day, A., Valenstein, E., Hammond, E., & Duara, R. (1990). Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia. Neuropsychologia, 28(2), 161-169. https://doi.org/10.1016/0028-3932(90)90098-9

Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia. / Heilman, Kenneth M.; Bowers, Dawn; Watson, Robert T.; Day, Arthur; Valenstein, Edward; Hammond, Edward; Duara, Ranjan.

In: Neuropsychologia, Vol. 28, No. 2, 01.01.1990, p. 161-169.

Research output: Contribution to journalArticle

Heilman, KM, Bowers, D, Watson, RT, Day, A, Valenstein, E, Hammond, E & Duara, R 1990, 'Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia', Neuropsychologia, vol. 28, no. 2, pp. 161-169. https://doi.org/10.1016/0028-3932(90)90098-9
Heilman, Kenneth M. ; Bowers, Dawn ; Watson, Robert T. ; Day, Arthur ; Valenstein, Edward ; Hammond, Edward ; Duara, Ranjan. / Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia. In: Neuropsychologia. 1990 ; Vol. 28, No. 2. pp. 161-169.
@article{e2bdc58f9d444798bda630e6e8311b43,
title = "Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia",
abstract = "A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.",
author = "Heilman, {Kenneth M.} and Dawn Bowers and Watson, {Robert T.} and Arthur Day and Edward Valenstein and Edward Hammond and Ranjan Duara",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0028-3932(90)90098-9",
language = "English",
volume = "28",
pages = "161--169",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

AU - Heilman, Kenneth M.

AU - Bowers, Dawn

AU - Watson, Robert T.

AU - Day, Arthur

AU - Valenstein, Edward

AU - Hammond, Edward

AU - Duara, Ranjan

PY - 1990/1/1

Y1 - 1990/1/1

N2 - A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.

AB - A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.

UR - http://www.scopus.com/inward/record.url?scp=0025327126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025327126&partnerID=8YFLogxK

U2 - 10.1016/0028-3932(90)90098-9

DO - 10.1016/0028-3932(90)90098-9

M3 - Article

VL - 28

SP - 161

EP - 169

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 2

ER -