Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

Kenneth M. Heilman; Dawn Bowers; Robert T. Watson; Arthur Day; Edward Valenstein; Edward Hammond; Ranjan Duara

doi:10.1016/0028-3932(90)90098-9

Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

Kenneth M. Heilman, Dawn Bowers, Robert T. Watson, Arthur Day, Edward Valenstein, Edward Hammond, Ranjan Duara

Medicine

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Abstract

A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.

Original language	English (US)
Pages (from-to)	161-169
Number of pages	9
Journal	Neuropsychologia
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/0028-3932(90)90098-9
State	Published - 1990

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ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

Cite this

Heilman, K. M., Bowers, D., Watson, R. T., Day, A., Valenstein, E., Hammond, E., & Duara, R. (1990). Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia. Neuropsychologia, 28(2), 161-169. https://doi.org/10.1016/0028-3932(90)90098-9

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10.1016/0028-3932(90)90098-9