Abstract
A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.
| Original language | English |
|---|---|
| Pages (from-to) | 161-169 |
| Number of pages | 9 |
| Journal | Neuropsychologia |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
- Neuropsychology and Physiological Psychology
Cite this
Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia. / Heilman, Kenneth M.; Bowers, Dawn; Watson, Robert T.; Day, Arthur; Valenstein, Edward; Hammond, Edward; Duara, Ranjan.
In: Neuropsychologia, Vol. 28, No. 2, 01.01.1990, p. 161-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia
AU - Heilman, Kenneth M.
AU - Bowers, Dawn
AU - Watson, Robert T.
AU - Day, Arthur
AU - Valenstein, Edward
AU - Hammond, Edward
AU - Duara, Ranjan
PY - 1990/1/1
Y1 - 1990/1/1
N2 - A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.
AB - A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.
UR - http://www.scopus.com/inward/record.url?scp=0025327126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025327126&partnerID=8YFLogxK
U2 - 10.1016/0028-3932(90)90098-9
DO - 10.1016/0028-3932(90)90098-9
M3 - Article
VL - 28
SP - 161
EP - 169
JO - Neuropsychologia
JF - Neuropsychologia
SN - 0028-3932
IS - 2
ER -