Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

Kenneth M. Heilman, Dawn Bowers, Robert T. Watson, Arthur Day, Edward Valenstein, Edward Hammond, Ranjan Duara

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Abstract

A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalNeuropsychologia
Volume28
Issue number2
DOIs
StatePublished - 1990

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ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Heilman, K. M., Bowers, D., Watson, R. T., Day, A., Valenstein, E., Hammond, E., & Duara, R. (1990). Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia. Neuropsychologia, 28(2), 161-169. https://doi.org/10.1016/0028-3932(90)90098-9