From the archives of the AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologie-pathologic correlation

Mark D. Murphey, George C. Nomikos, Donald J. Flemming, Francis H. Gannon, H. Thomas Temple, Mark J. Kransdorf

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

The radiologic features of giant cell tumor (GCT) and giant cell reparative granuloma (GCRG) of bone often strongly suggest the diagnosis and reflect their pathologic appearance. At radiography, GCT often demonstrates a metaepiphyseal location with extension to subchondral bone. GCRG has a similar appearance but most commonly affects the mandible, maxilla, hands, or feet. Computed tomography and magnetic resonance (MR) imaging are helpful in staging lesions, particularly in delineating soft-tissue extension. Cystic (secondary aneurysmal bone cyst) components are reported in 14% of GCTs. However, biopsy must be directed at the solid regions, which harbor diagnostic tissue. These solid components demonstrate low to intermediate signal intensity at T2-weighted MR imaging, a feature that can be helpful in diagnosis. Multiple GCTs, although rare, do occur and may be associated with Paget disease. Malignant GCT accounts for 5%-10% of all GCTs and is usually secondary to previous irradiation of benign GCT. Treatment of GCT usually consists of surgical resection. Recurrence is seen in 2%-25% of cases, and imaging is vital for early detection. Recognition of the spectrum of radiologic appearances of GCT and GCRG is important in allowing prospective diagnosis, guiding therapy, and facilitating early detection of recurrence.

Original languageEnglish
Pages (from-to)1283-1309
Number of pages27
JournalRadiographics
Volume21
Issue number5
StatePublished - Sep 1 2001

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Giant Cell Granuloma
Giant Cell Tumors
Bone and Bones
Magnetic Resonance Imaging
Aneurysmal Bone Cysts
Recurrence
Maxilla
Mandible
Radiography
Foot
Hand
Tomography
Biopsy

Keywords

  • Bone neoplasms, 20.274, 20.3182, 30.3182, 40.3182
  • Bone neoplasms, diagnosis, 40.11, 40.1211, 40.1214, 40.1216
  • Giant cell tumor, 20.3182, 30.3182, 40.3182
  • Granuloma, giant-cell reparative, 20.274

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Murphey, M. D., Nomikos, G. C., Flemming, D. J., Gannon, F. H., Thomas Temple, H., & Kransdorf, M. J. (2001). From the archives of the AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologie-pathologic correlation. Radiographics, 21(5), 1283-1309.

From the archives of the AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone : Radiologie-pathologic correlation. / Murphey, Mark D.; Nomikos, George C.; Flemming, Donald J.; Gannon, Francis H.; Thomas Temple, H.; Kransdorf, Mark J.

In: Radiographics, Vol. 21, No. 5, 01.09.2001, p. 1283-1309.

Research output: Contribution to journalArticle

Murphey, MD, Nomikos, GC, Flemming, DJ, Gannon, FH, Thomas Temple, H & Kransdorf, MJ 2001, 'From the archives of the AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologie-pathologic correlation', Radiographics, vol. 21, no. 5, pp. 1283-1309.
Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Thomas Temple H, Kransdorf MJ. From the archives of the AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologie-pathologic correlation. Radiographics. 2001 Sep 1;21(5):1283-1309.
Murphey, Mark D. ; Nomikos, George C. ; Flemming, Donald J. ; Gannon, Francis H. ; Thomas Temple, H. ; Kransdorf, Mark J. / From the archives of the AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone : Radiologie-pathologic correlation. In: Radiographics. 2001 ; Vol. 21, No. 5. pp. 1283-1309.
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abstract = "The radiologic features of giant cell tumor (GCT) and giant cell reparative granuloma (GCRG) of bone often strongly suggest the diagnosis and reflect their pathologic appearance. At radiography, GCT often demonstrates a metaepiphyseal location with extension to subchondral bone. GCRG has a similar appearance but most commonly affects the mandible, maxilla, hands, or feet. Computed tomography and magnetic resonance (MR) imaging are helpful in staging lesions, particularly in delineating soft-tissue extension. Cystic (secondary aneurysmal bone cyst) components are reported in 14{\%} of GCTs. However, biopsy must be directed at the solid regions, which harbor diagnostic tissue. These solid components demonstrate low to intermediate signal intensity at T2-weighted MR imaging, a feature that can be helpful in diagnosis. Multiple GCTs, although rare, do occur and may be associated with Paget disease. Malignant GCT accounts for 5{\%}-10{\%} of all GCTs and is usually secondary to previous irradiation of benign GCT. Treatment of GCT usually consists of surgical resection. Recurrence is seen in 2{\%}-25{\%} of cases, and imaging is vital for early detection. Recognition of the spectrum of radiologic appearances of GCT and GCRG is important in allowing prospective diagnosis, guiding therapy, and facilitating early detection of recurrence.",
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