From stones to bones

The biology of CIC chloride channels

Alfred L. George,, Laura Bianchi, Elizabeth M. Link, Carlos G. Vanoye

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Chloride (Cl -) is the most abundant extracellular anion in multicellular organisms. Passive movement of Cl -through membrane ion channels enables several cellular and physiological processes including transepithelial salt transport, electrical excitability, cell volume regulation and acidification of internal and external compartments. One family of proteins mediating Cl - permeability, the CIC channels, has emerged as important for all of these biological processes. The importance of CIC channels has in part been realized through studies of inherited human diseases and genetically engineered mice that display a wide range of phenotypes from kidney stones to petrified bones. These recent findings have demonstrated many eclectic functions of CIC channels and have placed Cl - channels in the physiological limelight.

Original languageEnglish
JournalCurrent Biology
Volume11
Issue number15
DOIs
StatePublished - Aug 7 2001
Externally publishedYes

Fingerprint

renal calculi
chloride channels
Chloride Channels
Acidification
ion channels
Ion Channels
human diseases
anions
acidification
Anions
Chlorides
permeability
chlorides
Bone
Salts
bones
Physiological Phenomena
salts
Membranes
Biological Phenomena

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

From stones to bones : The biology of CIC chloride channels. / George, Alfred L.; Bianchi, Laura; Link, Elizabeth M.; Vanoye, Carlos G.

In: Current Biology, Vol. 11, No. 15, 07.08.2001.

Research output: Contribution to journalArticle

George, Alfred L. ; Bianchi, Laura ; Link, Elizabeth M. ; Vanoye, Carlos G. / From stones to bones : The biology of CIC chloride channels. In: Current Biology. 2001 ; Vol. 11, No. 15.
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