From guidelines to clinical practice

The impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes - The Global Registry of Acute Coronary Events (GRACE)

Keith A A Fox, Shaun G. Goodman, Frederick A. Anderson, Christopher B. Granger, Mauro Moscucci, Marcus D. Flather, Frederick Spencer, Andrzej Budaj, Omar H. Dabbous, Joel M. Gore

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

Aims: The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are modifiable, remain uncertain. Methods and results: Using chronological data from the GRACE registry (n=12 666, July 1999 to December 2001), we test the hypothesis that hospital and geographic characteristics influence the time course of uptake of evidence-based guideline recommendations for acute coronary syndromes (ACS) with and without ST elevation. Certain therapies were widely adopted in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) patients (aspirin >94% of all patients; beta-blockers 85-95%) and changed only modestly over time. Significant increases in the use of low-molecular-weight heparins and glycoprotein IIb/IIIa inhibitors occurred in STEMI and NSTEMI patients in advance of published practice guidelines (September/November 2000) with marked geographical differences. The highest use of LMWH was in Europe in NSTEMI (86.8%) and the lowest in the USA (24.0%). Contrasting geographical variations were seen in the use of percutaneous coronary intervention (PCI) in NSTEMI: 39.5% USA, 34.6% Europe, 33.5% Argentina/Brazil, 25.0% Australia/New Zealand/Canada (July-December 2001). The use of PCI was more than five times greater in hospitals with an on-site catheterization laboratory compared to centres without these facilities, and geographic differences remained after correction for available facilities. Conclusions: Hospital and geographical factors appear to have a marked influence on the uptake of evidence-based therapies in ACS management. The presentation and publication of major international guidelines was not associated with a measurable change in the temporal pattern of practice. In contrast, antithrombotic and interventional therapies changed markedly over time and were profoundly influenced by hospital and geographic characteristics.

Original languageEnglish
Pages (from-to)1414-1424
Number of pages11
JournalEuropean Heart Journal
Volume24
Issue number15
DOIs
StatePublished - Aug 1 2003

Fingerprint

Acute Coronary Syndrome
Registries
Guidelines
Low Molecular Weight Heparin
Percutaneous Coronary Intervention
Practice Guidelines
Platelet Glycoprotein GPIIb-IIIa Complex
Argentina
New Zealand
Catheterization
Aspirin
Canada
Brazil
Publications
Therapeutics
Myocardial Infarction
Clinical Trials
Non-ST Elevated Myocardial Infarction

Keywords

  • Acute coronary syndromes
  • Catheterization laboratory
  • Glycoprotein IIb/IIIa inhibitors
  • Guidelines
  • Low-molecular-weight heparin
  • Percutaneous coronary intervention
  • Temporal trends

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

From guidelines to clinical practice : The impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes - The Global Registry of Acute Coronary Events (GRACE). / Fox, Keith A A; Goodman, Shaun G.; Anderson, Frederick A.; Granger, Christopher B.; Moscucci, Mauro; Flather, Marcus D.; Spencer, Frederick; Budaj, Andrzej; Dabbous, Omar H.; Gore, Joel M.

In: European Heart Journal, Vol. 24, No. 15, 01.08.2003, p. 1414-1424.

Research output: Contribution to journalArticle

Fox, Keith A A ; Goodman, Shaun G. ; Anderson, Frederick A. ; Granger, Christopher B. ; Moscucci, Mauro ; Flather, Marcus D. ; Spencer, Frederick ; Budaj, Andrzej ; Dabbous, Omar H. ; Gore, Joel M. / From guidelines to clinical practice : The impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes - The Global Registry of Acute Coronary Events (GRACE). In: European Heart Journal. 2003 ; Vol. 24, No. 15. pp. 1414-1424.
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abstract = "Aims: The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are modifiable, remain uncertain. Methods and results: Using chronological data from the GRACE registry (n=12 666, July 1999 to December 2001), we test the hypothesis that hospital and geographic characteristics influence the time course of uptake of evidence-based guideline recommendations for acute coronary syndromes (ACS) with and without ST elevation. Certain therapies were widely adopted in both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) patients (aspirin >94{\%} of all patients; beta-blockers 85-95{\%}) and changed only modestly over time. Significant increases in the use of low-molecular-weight heparins and glycoprotein IIb/IIIa inhibitors occurred in STEMI and NSTEMI patients in advance of published practice guidelines (September/November 2000) with marked geographical differences. The highest use of LMWH was in Europe in NSTEMI (86.8{\%}) and the lowest in the USA (24.0{\%}). Contrasting geographical variations were seen in the use of percutaneous coronary intervention (PCI) in NSTEMI: 39.5{\%} USA, 34.6{\%} Europe, 33.5{\%} Argentina/Brazil, 25.0{\%} Australia/New Zealand/Canada (July-December 2001). The use of PCI was more than five times greater in hospitals with an on-site catheterization laboratory compared to centres without these facilities, and geographic differences remained after correction for available facilities. Conclusions: Hospital and geographical factors appear to have a marked influence on the uptake of evidence-based therapies in ACS management. The presentation and publication of major international guidelines was not associated with a measurable change in the temporal pattern of practice. In contrast, antithrombotic and interventional therapies changed markedly over time and were profoundly influenced by hospital and geographic characteristics.",
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