From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia

D. Hoogewijs, N. B. Terwilliger, K. A. Webster, J. A. Powell-Coffman, S. Tokishita, H. Yamagata, T. Hankeln, T. Burmester, K. T. Rytknen, M. Nikinmaa, D. Abele, K. Heise, M. Lucassen, J. Fandrey, P. H. Maxwell, S. Phlman, T. A. Gorr

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Abstract

The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O2 sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)552-577
Number of pages26
JournalIntegrative and comparative biology
Volume47
Issue number4
DOIs
StatePublished - Oct 1 2007

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ASJC Scopus subject areas

  • Animal Science and Zoology
  • Plant Science

Cite this

Hoogewijs, D., Terwilliger, N. B., Webster, K. A., Powell-Coffman, J. A., Tokishita, S., Yamagata, H., Hankeln, T., Burmester, T., Rytknen, K. T., Nikinmaa, M., Abele, D., Heise, K., Lucassen, M., Fandrey, J., Maxwell, P. H., Phlman, S., & Gorr, T. A. (2007). From critters to cancers: Bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia. Integrative and comparative biology, 47(4), 552-577. https://doi.org/10.1093/icb/icm072