Frequent occurrence of hypoplasttc optic disks in patients with aniridia

Paul R. Layman, Douglas R. Anderson, John T. Flynn

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Of 12 patients with congenital aniridia seen at the Bascom Palmer Eye Institute, nine had disks of small diameter, representing hypoplasia of the optic nerve. The small size of the disk is difficult to recognize, and may easily be overlooked unless specific attention is paid to the size of the disk in relation to the diameter of the vessels and the vessel patterns. Since the iris pigment epithelium and musculature is derived from the neuroectoderm, as is the retina, there might be abnormalities in retinal development associated with abnormal iris development, and hypoplasia of the optic nerve may be the logical consequence of incomplete retinal development (especially in the macula) with a reduced number of nerve fibers passing from the retina into the optic nerve.

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalAmerican journal of ophthalmology
Issue number4
StatePublished - Apr 1974

ASJC Scopus subject areas

  • Ophthalmology


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