Abstract
The epidemiology of ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) must be explored from multiple aspects, each of which contributes insights into the problem and no one of which exerts exclusive dominance far preventive or therapeutic strategies. These include: (1) population dynamics, using conventional epidemiologic approaches; (2) risk as a function of time from an index event; (3) conditioning risk factors, based on the presence of underlying disease states; (4) transient risk factors that are dynamic and trigger a potentially fatal event at a specific point in time; and (5) 'response risk,' which refers to individual susceptibility (possibly determined genetically) to the adverse effects of longitudinal and/or dynamic risk factors. Major inroads into profiling individual or population risk of SCD will require better understanding of each of these epidemiologic-clinical-physiologic interactions. The disciplines range from epidemiology, through clinical medicine, to membrane channel physiology, genetic determinants, and molecular biology.
| Original language | English |
|---|---|
| Journal | American Journal of Cardiology |
| Volume | 80 |
| Issue number | 5 B |
| DOIs | |
| State | Published - Sep 11 1997 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Frequency of sudden cardiac death and profiles of risk. / Myerburg, Robert J; Interian, Alberto; Mitrani, Raul; Kessler, Kenneth M.; Castellanos, Agustin.
In: American Journal of Cardiology, Vol. 80, No. 5 B, 11.09.1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency of sudden cardiac death and profiles of risk
AU - Myerburg, Robert J
AU - Interian, Alberto
AU - Mitrani, Raul
AU - Kessler, Kenneth M.
AU - Castellanos, Agustin
PY - 1997/9/11
Y1 - 1997/9/11
N2 - The epidemiology of ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) must be explored from multiple aspects, each of which contributes insights into the problem and no one of which exerts exclusive dominance far preventive or therapeutic strategies. These include: (1) population dynamics, using conventional epidemiologic approaches; (2) risk as a function of time from an index event; (3) conditioning risk factors, based on the presence of underlying disease states; (4) transient risk factors that are dynamic and trigger a potentially fatal event at a specific point in time; and (5) 'response risk,' which refers to individual susceptibility (possibly determined genetically) to the adverse effects of longitudinal and/or dynamic risk factors. Major inroads into profiling individual or population risk of SCD will require better understanding of each of these epidemiologic-clinical-physiologic interactions. The disciplines range from epidemiology, through clinical medicine, to membrane channel physiology, genetic determinants, and molecular biology.
AB - The epidemiology of ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) must be explored from multiple aspects, each of which contributes insights into the problem and no one of which exerts exclusive dominance far preventive or therapeutic strategies. These include: (1) population dynamics, using conventional epidemiologic approaches; (2) risk as a function of time from an index event; (3) conditioning risk factors, based on the presence of underlying disease states; (4) transient risk factors that are dynamic and trigger a potentially fatal event at a specific point in time; and (5) 'response risk,' which refers to individual susceptibility (possibly determined genetically) to the adverse effects of longitudinal and/or dynamic risk factors. Major inroads into profiling individual or population risk of SCD will require better understanding of each of these epidemiologic-clinical-physiologic interactions. The disciplines range from epidemiology, through clinical medicine, to membrane channel physiology, genetic determinants, and molecular biology.
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U2 - 10.1016/S0002-9149(97)00477-3
DO - 10.1016/S0002-9149(97)00477-3
M3 - Article
C2 - 9291445
AN - SCOPUS:0030820117
VL - 80
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 5 B
ER -