Abstract
Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 10 6 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 205-207 |
| Number of pages | 3 |
| Journal | American Journal of Hematology |
| Volume | 55 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1997 |
| Externally published | Yes |
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Keywords
- BCL-2
- Follicular lymphoma
- PCR
- Translocations
ASJC Scopus subject areas
- Hematology
Cite this
Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients. / Zhang, Xian Yang; Safah, Hana; Mudad, Raja; Maher, Ellen; Krause, John; Miller, Alan; Ehrlich, Melanie.
In: American Journal of Hematology, Vol. 55, No. 4, 08.1997, p. 205-207.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients
AU - Zhang, Xian Yang
AU - Safah, Hana
AU - Mudad, Raja
AU - Maher, Ellen
AU - Krause, John
AU - Miller, Alan
AU - Ehrlich, Melanie
PY - 1997/8
Y1 - 1997/8
N2 - Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 10 6 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.
AB - Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 10 6 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.
KW - BCL-2
KW - Follicular lymphoma
KW - PCR
KW - Translocations
UR - http://www.scopus.com/inward/record.url?scp=0030805849&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030805849&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8652(199707)55:4<205::AID-AJH7>3.0.CO;2-W
DO - 10.1002/(SICI)1096-8652(199707)55:4<205::AID-AJH7>3.0.CO;2-W
M3 - Article
C2 - 9257881
AN - SCOPUS:0030805849
VL - 55
SP - 205
EP - 207
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 4
ER -