Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients

Xian Yang Zhang, Hana Safah, Raja Mudad, Ellen Maher, John Krause, Alan Miller, Melanie Ehrlich

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 106 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalAmerican Journal of Hematology
Volume55
Issue number4
DOIs
StatePublished - Aug 1 1997
Externally publishedYes

Keywords

  • BCL-2
  • Follicular lymphoma
  • PCR
  • Translocations

ASJC Scopus subject areas

  • Hematology

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