Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients

Xian Yang Zhang; Hana Safah; Raja Mudad; Ellen Maher; John Krause; Alan Miller; Melanie Ehrlich

doi:10.1002/(SICI)1096-8652(199707)55:4<205::AID-AJH7>3.0.CO;2-W

Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients

Xian Yang Zhang, Hana Safah, Raja Mudad, Ellen Maher, John Krause, Alan Miller, Melanie Ehrlich

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 10⁶ PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.

Original language	English (US)
Pages (from-to)	205-207
Number of pages	3
Journal	American Journal of Hematology
Volume	55
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1096-8652(199707)55:4<205::AID-AJH7>3.0.CO;2-W
State	Published - Aug 1997
Externally published	Yes

Keywords

BCL-2
Follicular lymphoma
PCR
Translocations

ASJC Scopus subject areas

Hematology

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10.1002/(SICI)1096-8652(199707)55:4<205::AID-AJH7>3.0.CO;2-W

Cite this

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title = "Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients",

abstract = "Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 106 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.",

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T1 - Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients

AU - Zhang, Xian Yang

AU - Safah, Hana

AU - Mudad, Raja

AU - Maher, Ellen

AU - Krause, John

AU - Miller, Alan

AU - Ehrlich, Melanie

PY - 1997/8

Y1 - 1997/8

N2 - Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 106 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.

AB - Polymerase chain reaction (PCR) assays have been developed for follicular lymphoma associated BCL-2/J(H)translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 x 106 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later.

KW - BCL-2

KW - Follicular lymphoma

KW - PCR

KW - Translocations

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Frequency of BCL-2/J(H) translocations in peripheral blood of follicular lymphoma patients

Abstract

Keywords

ASJC Scopus subject areas

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