Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study

Shawn M. Iverson, William J. Feuer, Wei Shi, David S. Greenfield

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background/aims: To examine the frequency of abnormal retinal nerve fibre layer thickness (RNFLT) and ganglion cell complex (GCC) measurements among healthy and glaucoma suspect and preperimetric glaucoma (GSPPG) eyes in a prospective longitudinal study. Methods: Normal and GSPPG eyes with ≥18 months follow-up were included. Spectral-domain optical coherence tomography (SDOCT) was performed annually in normal and biannually in GSPPG eyes. One eye was randomly selected for inclusion. RNFLT and GCC parameters with p>5% were classifi ed as 'within normal limits (WNL) ' and p<1% were classified as 'outside normal limits (ONL)'. Results: 23 normal and 74 GSPPG eyes were followed for a mean 43.4±9.6 months. During serial follow-up, 100% and 91% of normal eyes had all RNFLT and GCC parameters classified as WNL, respectively. 27 (37%) and 17 (23%) of GSPPG eyes had an ONL classification in at least one RNFLT and GCC parameter, respectively. A high percentage (41%-56%) of RNFLT and GCC measurements classified as ONL were not replicated on subsequent scans. The rates of loss for all parameters were similar (p>0.05) between the groups. Conclusions: Specificity in this sample of healthy eyes was very high for RNFLT and GCC parameters. Confirmation of suspected SDOCT abnormalities is recommended to differentiate reproducible loss from long-term variability.

Original languageEnglish (US)
Pages (from-to)920-925
Number of pages6
JournalBritish Journal of Ophthalmology
Volume98
Issue number7
DOIs
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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