Frequency gradients during two different forms of fibrillation in the canine atria

Joseph S. Ulphani, Jason Ng, Rahul Aggarwal, Jack H. Cain, David Gordon, Eric Yang, Alexander R. Morris, Rishi Arora, Jeffrey Goldberger, Alan H. Kadish

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Atrial fibrillation (AF) is thought to be sustained by multiple reentrant wavelets or firing foci. Objective: The aim of this study was to compare the spectral domain characteristics in the left atrium (LA) and right atrium (RA) in two different models of AF. Methods: Rectangular 8 × 14 electrode arrays were placed on the LA and RA of 14 anesthetized dogs. AF episodes were induced with burst pacing and aconitine in each dog. For each model, AF was induced from the RA in six dogs and from the LA in six dogs. Dominant frequencies (DFs) were obtained using the fast Fourier transform of the unipolar recordings obtained from each electrode of the array. Standard deviation (SD) was used to compute the frequency dispersion within an atrium. Regularity of the signal was quantified using an organization index (OI). Results: DFs were largest in the atrium where aconitine was applied. Aconitine AF had larger gradients than burst-pacing AF (5.0 ± 4.5 vs. 0.9 ± 1.0 Hz: P <.006). Aconitine AF when compared with burst-pacing AF had greater absolute LA-RA differences in the SD of DFs (2.3 ± 1.9 vs. 0.2 ± 0.2 Hz; P <.001) and in OI (0.11 ± 0.07 vs. 0.06 ± 0.07; P <.07). Conclusions: Differences in frequency gradients and organization were observed during AF induced by burst pacing and aconitine. This suggests that different mechanisms of AF are possible and may be identified with frequency domain analysis.

Original languageEnglish (US)
Pages (from-to)1315-1323
Number of pages9
JournalHeart Rhythm
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

Fingerprint

Atrial Fibrillation
Canidae
Heart Atria
Aconitine
Dogs
Electrodes
Fourier Analysis

Keywords

  • Atrial fibrillation
  • Organization
  • Spectral analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Ulphani, J. S., Ng, J., Aggarwal, R., Cain, J. H., Gordon, D., Yang, E., ... Kadish, A. H. (2007). Frequency gradients during two different forms of fibrillation in the canine atria. Heart Rhythm, 4(10), 1315-1323. https://doi.org/10.1016/j.hrthm.2007.06.007

Frequency gradients during two different forms of fibrillation in the canine atria. / Ulphani, Joseph S.; Ng, Jason; Aggarwal, Rahul; Cain, Jack H.; Gordon, David; Yang, Eric; Morris, Alexander R.; Arora, Rishi; Goldberger, Jeffrey; Kadish, Alan H.

In: Heart Rhythm, Vol. 4, No. 10, 01.10.2007, p. 1315-1323.

Research output: Contribution to journalArticle

Ulphani, JS, Ng, J, Aggarwal, R, Cain, JH, Gordon, D, Yang, E, Morris, AR, Arora, R, Goldberger, J & Kadish, AH 2007, 'Frequency gradients during two different forms of fibrillation in the canine atria', Heart Rhythm, vol. 4, no. 10, pp. 1315-1323. https://doi.org/10.1016/j.hrthm.2007.06.007
Ulphani JS, Ng J, Aggarwal R, Cain JH, Gordon D, Yang E et al. Frequency gradients during two different forms of fibrillation in the canine atria. Heart Rhythm. 2007 Oct 1;4(10):1315-1323. https://doi.org/10.1016/j.hrthm.2007.06.007
Ulphani, Joseph S. ; Ng, Jason ; Aggarwal, Rahul ; Cain, Jack H. ; Gordon, David ; Yang, Eric ; Morris, Alexander R. ; Arora, Rishi ; Goldberger, Jeffrey ; Kadish, Alan H. / Frequency gradients during two different forms of fibrillation in the canine atria. In: Heart Rhythm. 2007 ; Vol. 4, No. 10. pp. 1315-1323.
@article{76031dd040c04625875fdd6611973aca,
title = "Frequency gradients during two different forms of fibrillation in the canine atria",
abstract = "Background: Atrial fibrillation (AF) is thought to be sustained by multiple reentrant wavelets or firing foci. Objective: The aim of this study was to compare the spectral domain characteristics in the left atrium (LA) and right atrium (RA) in two different models of AF. Methods: Rectangular 8 × 14 electrode arrays were placed on the LA and RA of 14 anesthetized dogs. AF episodes were induced with burst pacing and aconitine in each dog. For each model, AF was induced from the RA in six dogs and from the LA in six dogs. Dominant frequencies (DFs) were obtained using the fast Fourier transform of the unipolar recordings obtained from each electrode of the array. Standard deviation (SD) was used to compute the frequency dispersion within an atrium. Regularity of the signal was quantified using an organization index (OI). Results: DFs were largest in the atrium where aconitine was applied. Aconitine AF had larger gradients than burst-pacing AF (5.0 ± 4.5 vs. 0.9 ± 1.0 Hz: P <.006). Aconitine AF when compared with burst-pacing AF had greater absolute LA-RA differences in the SD of DFs (2.3 ± 1.9 vs. 0.2 ± 0.2 Hz; P <.001) and in OI (0.11 ± 0.07 vs. 0.06 ± 0.07; P <.07). Conclusions: Differences in frequency gradients and organization were observed during AF induced by burst pacing and aconitine. This suggests that different mechanisms of AF are possible and may be identified with frequency domain analysis.",
keywords = "Atrial fibrillation, Organization, Spectral analysis",
author = "Ulphani, {Joseph S.} and Jason Ng and Rahul Aggarwal and Cain, {Jack H.} and David Gordon and Eric Yang and Morris, {Alexander R.} and Rishi Arora and Jeffrey Goldberger and Kadish, {Alan H.}",
year = "2007",
month = "10",
day = "1",
doi = "10.1016/j.hrthm.2007.06.007",
language = "English (US)",
volume = "4",
pages = "1315--1323",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "10",

}

TY - JOUR

T1 - Frequency gradients during two different forms of fibrillation in the canine atria

AU - Ulphani, Joseph S.

AU - Ng, Jason

AU - Aggarwal, Rahul

AU - Cain, Jack H.

AU - Gordon, David

AU - Yang, Eric

AU - Morris, Alexander R.

AU - Arora, Rishi

AU - Goldberger, Jeffrey

AU - Kadish, Alan H.

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Background: Atrial fibrillation (AF) is thought to be sustained by multiple reentrant wavelets or firing foci. Objective: The aim of this study was to compare the spectral domain characteristics in the left atrium (LA) and right atrium (RA) in two different models of AF. Methods: Rectangular 8 × 14 electrode arrays were placed on the LA and RA of 14 anesthetized dogs. AF episodes were induced with burst pacing and aconitine in each dog. For each model, AF was induced from the RA in six dogs and from the LA in six dogs. Dominant frequencies (DFs) were obtained using the fast Fourier transform of the unipolar recordings obtained from each electrode of the array. Standard deviation (SD) was used to compute the frequency dispersion within an atrium. Regularity of the signal was quantified using an organization index (OI). Results: DFs were largest in the atrium where aconitine was applied. Aconitine AF had larger gradients than burst-pacing AF (5.0 ± 4.5 vs. 0.9 ± 1.0 Hz: P <.006). Aconitine AF when compared with burst-pacing AF had greater absolute LA-RA differences in the SD of DFs (2.3 ± 1.9 vs. 0.2 ± 0.2 Hz; P <.001) and in OI (0.11 ± 0.07 vs. 0.06 ± 0.07; P <.07). Conclusions: Differences in frequency gradients and organization were observed during AF induced by burst pacing and aconitine. This suggests that different mechanisms of AF are possible and may be identified with frequency domain analysis.

AB - Background: Atrial fibrillation (AF) is thought to be sustained by multiple reentrant wavelets or firing foci. Objective: The aim of this study was to compare the spectral domain characteristics in the left atrium (LA) and right atrium (RA) in two different models of AF. Methods: Rectangular 8 × 14 electrode arrays were placed on the LA and RA of 14 anesthetized dogs. AF episodes were induced with burst pacing and aconitine in each dog. For each model, AF was induced from the RA in six dogs and from the LA in six dogs. Dominant frequencies (DFs) were obtained using the fast Fourier transform of the unipolar recordings obtained from each electrode of the array. Standard deviation (SD) was used to compute the frequency dispersion within an atrium. Regularity of the signal was quantified using an organization index (OI). Results: DFs were largest in the atrium where aconitine was applied. Aconitine AF had larger gradients than burst-pacing AF (5.0 ± 4.5 vs. 0.9 ± 1.0 Hz: P <.006). Aconitine AF when compared with burst-pacing AF had greater absolute LA-RA differences in the SD of DFs (2.3 ± 1.9 vs. 0.2 ± 0.2 Hz; P <.001) and in OI (0.11 ± 0.07 vs. 0.06 ± 0.07; P <.07). Conclusions: Differences in frequency gradients and organization were observed during AF induced by burst pacing and aconitine. This suggests that different mechanisms of AF are possible and may be identified with frequency domain analysis.

KW - Atrial fibrillation

KW - Organization

KW - Spectral analysis

UR - http://www.scopus.com/inward/record.url?scp=34648833629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34648833629&partnerID=8YFLogxK

U2 - 10.1016/j.hrthm.2007.06.007

DO - 10.1016/j.hrthm.2007.06.007

M3 - Article

C2 - 17905337

AN - SCOPUS:34648833629

VL - 4

SP - 1315

EP - 1323

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 10

ER -