Free protein s deficiency in acute ischemic stroke

A. Case Control Study, Stephan A. Mayer, Ralph L. Sacco, Ann Hurlet-Jensen, Tianying Shi, J. P. Mohr

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Background and Purpose: Deficiency of free protein S, a naturally occurring anticoagulant, may be acquired in the setting of acute illness and increasingly has become recognized as a possible stroke risk factor. We sought to determine whether free protein S deficiency is associated with acute cerebral infarction among older individuals at risk for stroke. Methods: Free protein S was measured by Laurell rocket immunoelectrophoresis in 94 adults admitted for acute cerebral infarction and in 94 hospitalized control subjects of similar age, sex, and race. Patients with a history of cerebrovascular disease, acute thrombotic or hematologic diseases, or medical conditions known to cause free protein S deficiency were excluded from the control group. Results: The percentage of patients with free protein S deficiency (<20% normal total protein S) was similar in the case and control groups (21% versus 20%, respectively). Among all subjects, free protein S deficiency was more common in blacks than nonblacks (34% versus 13%,p=0.001). A very low free protein S (<15% normal total protein S) was more frequent among case patients than control subjects (11% versus 5%), but this trend failed to reach statistical significance. Conclusions: Free protein S deficiency is common among hospitalized patients, even in the absence of a recognized predisposing condition. Our findings indicate that acquired deficiency of free protein S is not a major risk factor for ischemic stroke.

Original languageEnglish (US)
Pages (from-to)224-227
Number of pages4
Issue number2
StatePublished - Feb 1993
Externally publishedYes


  • Blood proteins
  • Cerebral ischemia
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


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