Free protein S deficiency: A possible association with cerebrovascular occlusion

Ralph L. Sacco, John Owen, J. P. Mohr, Thomas K. Tatemichi, Betty A. Grossman

Research output: Contribution to journalArticle

75 Scopus citations


A deficiency of free protein S, known to increase the risk of peripheral venous thrombosis, has not been well described in patients with cerebrovascular disease. In a pilot study of 35 patients with symptomatic cerebrovascular disease, using a qualitative crossed immunoelectrophoresis assay we found eight patients with a free protein S deficiency. A Laurell immunoelectrophoresis assay was used to quantify the percentage of free protein S after removal of the inactive protein S C4b-binding protein complex by precipitation with polyethylene glycol 8000. In a quantitative study of 103 patients with cerebrovascular disease, 21 had a free protein S that was <20% of the average normal total protein S concentration (normal range 20-40%); 19 had suffered cerebral infarction and the other two had suffered intracranial hemorrage. The frequency of free protein S deficiency in this group of stroke patients was far higher than the expected prevalence in the general population.

Original languageEnglish (US)
Pages (from-to)1657-1661
Number of pages5
Issue number12
StatePublished - Dec 1989


  • blood coagulation disorders
  • Cerebrovascular disorders
  • protein S

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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