Abstract
In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.
| Original language | English |
|---|---|
| Pages (from-to) | 483-487 |
| Number of pages | 5 |
| Journal | Clinical Pharmacology and Therapeutics |
| Volume | 31 |
| Issue number | 4 |
| State | Published - Apr 1 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Free and bound choline blood levels after phosphatidylcholine. / Jope, Richard S; Domino, Edward F.; Mathews, Benjamin N.; Sitaram, Natraj; Jenden, Donald J.; Ortez, Aurelio.
In: Clinical Pharmacology and Therapeutics, Vol. 31, No. 4, 01.04.1982, p. 483-487.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Free and bound choline blood levels after phosphatidylcholine
AU - Jope, Richard S
AU - Domino, Edward F.
AU - Mathews, Benjamin N.
AU - Sitaram, Natraj
AU - Jenden, Donald J.
AU - Ortez, Aurelio
PY - 1982/4/1
Y1 - 1982/4/1
N2 - In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.
AB - In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.
UR - http://www.scopus.com/inward/record.url?scp=0020259309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020259309&partnerID=8YFLogxK
M3 - Article
VL - 31
SP - 483
EP - 487
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 4
ER -