Free and bound choline blood levels after phosphatidylcholine

Richard S. Jope, Edward F. Domino, Benjamin N. Mathews, Natraj Sitaram, Donald J. Jenden, Aurelio Ortez

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Abstract

In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.

Original languageEnglish (US)
Pages (from-to)483-487
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number4
DOIs
StatePublished - Apr 1982

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Jope, R. S., Domino, E. F., Mathews, B. N., Sitaram, N., Jenden, D. J., & Ortez, A. (1982). Free and bound choline blood levels after phosphatidylcholine. Clinical Pharmacology and Therapeutics, 31(4), 483-487. https://doi.org/10.1038/clpt.1982.64