Free and bound choline blood levels after phosphatidylcholine

Richard S Jope, Edward F. Domino, Benjamin N. Mathews, Natraj Sitaram, Donald J. Jenden, Aurelio Ortez

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume31
Issue number4
StatePublished - Apr 1 1982
Externally publishedYes

Fingerprint

Choline
Phosphatidylcholines
Erythrocytes
Lipids
Lecithins

ASJC Scopus subject areas

  • Pharmacology

Cite this

Jope, R. S., Domino, E. F., Mathews, B. N., Sitaram, N., Jenden, D. J., & Ortez, A. (1982). Free and bound choline blood levels after phosphatidylcholine. Clinical Pharmacology and Therapeutics, 31(4), 483-487.

Free and bound choline blood levels after phosphatidylcholine. / Jope, Richard S; Domino, Edward F.; Mathews, Benjamin N.; Sitaram, Natraj; Jenden, Donald J.; Ortez, Aurelio.

In: Clinical Pharmacology and Therapeutics, Vol. 31, No. 4, 01.04.1982, p. 483-487.

Research output: Contribution to journalArticle

Jope, RS, Domino, EF, Mathews, BN, Sitaram, N, Jenden, DJ & Ortez, A 1982, 'Free and bound choline blood levels after phosphatidylcholine', Clinical Pharmacology and Therapeutics, vol. 31, no. 4, pp. 483-487.
Jope RS, Domino EF, Mathews BN, Sitaram N, Jenden DJ, Ortez A. Free and bound choline blood levels after phosphatidylcholine. Clinical Pharmacology and Therapeutics. 1982 Apr 1;31(4):483-487.
Jope, Richard S ; Domino, Edward F. ; Mathews, Benjamin N. ; Sitaram, Natraj ; Jenden, Donald J. ; Ortez, Aurelio. / Free and bound choline blood levels after phosphatidylcholine. In: Clinical Pharmacology and Therapeutics. 1982 ; Vol. 31, No. 4. pp. 483-487.
@article{88e769c31b7c4198a3eac65029d6cecc,
title = "Free and bound choline blood levels after phosphatidylcholine",
abstract = "In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.",
author = "Jope, {Richard S} and Domino, {Edward F.} and Mathews, {Benjamin N.} and Natraj Sitaram and Jenden, {Donald J.} and Aurelio Ortez",
year = "1982",
month = "4",
day = "1",
language = "English",
volume = "31",
pages = "483--487",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Free and bound choline blood levels after phosphatidylcholine

AU - Jope, Richard S

AU - Domino, Edward F.

AU - Mathews, Benjamin N.

AU - Sitaram, Natraj

AU - Jenden, Donald J.

AU - Ortez, Aurelio

PY - 1982/4/1

Y1 - 1982/4/1

N2 - In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.

AB - In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Erythrocyte choline levels also rose, although the rise was slightly delayed relative to plasma choline. There was no change in the plasma choline-containing lipid concentration. These results demonstrate that, in normal subjects, oral phosphatidylcholine induces prolonged rises in plasma and erythrocyte choline concentrations and is therefore useful when such effects are desired.

UR - http://www.scopus.com/inward/record.url?scp=0020259309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020259309&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 483

EP - 487

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 4

ER -