Forty-Three Fatalities Involving the Synthetic Cannabinoid, 5-Fluoro-ADB: Forensic Pathology and Toxicology Implications

Diane M. Boland, Lisa Reidy, Joshua M. Seither, Jay M. Radtke, Emma O. Lew

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Forty-three fatalities involving the potent synthetic cannabinoid, 5-Fluoro-ADB, are summarized. For each case, a description of the terminal event, autopsy findings, cause of death, qualitative identification of 5-Fluoro-ADB and its ester hydrolysis metabolite, 5-Fluoro-ADB metabolite 7, in urine, and the quantitative values obtained in the blood specimens are outlined. Central blood concentrations ranged from 0.010 to 2.2 ng/mL for 5-Fluoro-ADB and 2.0 to 166 ng/mL for 5-Fluoro-ADB metabolite 7. Peripheral blood concentrations ranged from 0.010 to 0.77 ng/mL and 2.0 to 110 ng/mL for 5-Fluoro-ADB and 5-Fluoro-ADB metabolite 7, respectively. The majority of cases resulted in central to peripheral blood concentration ratios greater than 1 for 5-Fluoro-ADB (58%) and 5-Fluoro-ADB metabolite 7 (71%) suggesting that postmortem redistribution occurs to some extent. Combining the increased cardiac weight and/or gastric volume and toxicology data identifying 5-Fluoro-ADB, it is hypothesized that abuse of this substance may precipitate a dysrhythmia and cause sudden death.

Original languageEnglish (US)
JournalJournal of Forensic Sciences
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • 5-Fluoro-ADB
  • forensic pathology
  • forensic science
  • forensic toxicology
  • postmortem redistribution
  • synthetic cannabinoids

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

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