Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9

J. Tschopp, H. J. Muller-Eberhard, E. R. Podack

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The ninth component of complement C9 can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalNature
Volume298
Issue number5874
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Complement C9
Polymerization
Complement System Proteins
Membranes
Membrane Lipids
Proteins
complement C9 polymer

ASJC Scopus subject areas

  • General

Cite this

Tschopp, J., Muller-Eberhard, H. J., & Podack, E. R. (1982). Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9. Nature, 298(5874), 534-538.

Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9. / Tschopp, J.; Muller-Eberhard, H. J.; Podack, E. R.

In: Nature, Vol. 298, No. 5874, 01.01.1982, p. 534-538.

Research output: Contribution to journalArticle

Tschopp, J, Muller-Eberhard, HJ & Podack, ER 1982, 'Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9', Nature, vol. 298, no. 5874, pp. 534-538.
Tschopp J, Muller-Eberhard HJ, Podack ER. Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9. Nature. 1982 Jan 1;298(5874):534-538.
Tschopp, J. ; Muller-Eberhard, H. J. ; Podack, E. R. / Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9. In: Nature. 1982 ; Vol. 298, No. 5874. pp. 534-538.
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