Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9

Jürg Tschopp, Hans J. Müller-Eberhard, Eckhard R. Podack

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

The ninth component of complement C9 can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.

Original languageEnglish (US)
Pages (from-to)534-538
Number of pages5
JournalNature
Volume298
Issue number5874
DOIs
StatePublished - Dec 1 1982

ASJC Scopus subject areas

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