An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.
ASJC Scopus subject areas
- Cancer Research