Formation of solid human mammary carcinoma in vitro

R. A. Knazek, Marc E Lippman, H. C. Chopra

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalJournal of the National Cancer Institute
Volume58
Issue number2
StatePublished - Jan 1 1977
Externally publishedYes

Fingerprint

Breast Neoplasms
Neoplasms
Breast
Epithelial Cells
Cell Proliferation
Hormones
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Knazek, R. A., Lippman, M. E., & Chopra, H. C. (1977). Formation of solid human mammary carcinoma in vitro. Journal of the National Cancer Institute, 58(2), 419-422.

Formation of solid human mammary carcinoma in vitro. / Knazek, R. A.; Lippman, Marc E; Chopra, H. C.

In: Journal of the National Cancer Institute, Vol. 58, No. 2, 01.01.1977, p. 419-422.

Research output: Contribution to journalArticle

Knazek, RA, Lippman, ME & Chopra, HC 1977, 'Formation of solid human mammary carcinoma in vitro', Journal of the National Cancer Institute, vol. 58, no. 2, pp. 419-422.
Knazek RA, Lippman ME, Chopra HC. Formation of solid human mammary carcinoma in vitro. Journal of the National Cancer Institute. 1977 Jan 1;58(2):419-422.
Knazek, R. A. ; Lippman, Marc E ; Chopra, H. C. / Formation of solid human mammary carcinoma in vitro. In: Journal of the National Cancer Institute. 1977 ; Vol. 58, No. 2. pp. 419-422.
@article{c9c07224ccc041a996bc028bf3da1046,
title = "Formation of solid human mammary carcinoma in vitro",
abstract = "An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.",
author = "Knazek, {R. A.} and Lippman, {Marc E} and Chopra, {H. C.}",
year = "1977",
month = "1",
day = "1",
language = "English",
volume = "58",
pages = "419--422",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Formation of solid human mammary carcinoma in vitro

AU - Knazek, R. A.

AU - Lippman, Marc E

AU - Chopra, H. C.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.

AB - An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0017362353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017362353&partnerID=8YFLogxK

M3 - Article

C2 - 833887

AN - SCOPUS:0017362353

VL - 58

SP - 419

EP - 422

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 2

ER -