Formation of solid human mammary carcinoma in vitro

R. A. Knazek; M. E. Lippman; H. C. Chopra

doi:10.1093/jnci/58.2.419

Formation of solid human mammary carcinoma in vitro

R. A. Knazek, M. E. Lippman, H. C. Chopra

Medicine

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13 Scopus citations

Abstract

An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.

Original language	English (US)
Pages (from-to)	419-422
Number of pages	4
Journal	Journal of the National Cancer Institute
Volume	58
Issue number	2
DOIs	https://doi.org/10.1093/jnci/58.2.419
State	Published - Jan 1 1977

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ASJC Scopus subject areas

Oncology
Cancer Research

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Knazek, R. A., Lippman, M. E., & Chopra, H. C. (1977). Formation of solid human mammary carcinoma in vitro. Journal of the National Cancer Institute, 58(2), 419-422. https://doi.org/10.1093/jnci/58.2.419

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10.1093/jnci/58.2.419