Formation of solid human mammary carcinoma in vitro

R. A. Knazek, M. E. Lippman, H. C. Chopra

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalJournal of the National Cancer Institute
Issue number2
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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