TY - JOUR
T1 - Formation of solid human mammary carcinoma in vitro
AU - Knazek, R. A.
AU - Lippman, M. E.
AU - Chopra, H. C.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.
AB - An established line of human breast carcinoma, MCF-7, when cultured within the artificial capillary system, formed solid tissue masses. Acinar and ductular patterns developed, having the ultrastructural appearance of breast tissue that responds to exogenous hormones. In monolayers, the cells appear epithelial and form 'domes'* but in this system, the cells organize structures that appear to be ducts and acini. Cells grown in this manner also appear to retain the hormonal responsiveness previously described. Solid tumor formation within such a system may permit growth of large numbers of cells that reflect the characteristics of the tumor in vivo.
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U2 - 10.1093/jnci/58.2.419
DO - 10.1093/jnci/58.2.419
M3 - Article
C2 - 833887
AN - SCOPUS:0017362353
VL - 58
SP - 419
EP - 422
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 2
ER -
