Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau

Kentaro Tanemura, Takumi Akagi, Miyuki Murayama, Naomi Kikuchi, Ohoshi Murayama, Tsutomu Hashikawa, Yuji Yoshiike, Jung Mi Park, Keiko Matsuda, Shinobu Nakao, Xiaoyan Sun, Shinji Sato, Haruyasu Yamaguchi, Akihiko Takashima

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

Formation of neurofibrillary tangles (NFTs) is the most common feature in several neurodegenerative diseases, including Alzheimer's disease (AD). Here we report the formation of filamentous tau aggregations having a β-sheet structure in transgenic mice expressing mutant human tau. These mice contain a tau gene with a mutation of the frontotemporal dementia parkinsonism (FTDP-17) type, in which valine is substituted with methionine residue 337. The aggregation of tau in these transgenic mice satisfies all histological criteria used to identify NFTs common to human neurodegenerative diseases. These mice, therefore, provide a preclinical model for the testing of therapeutic drugs for the treatment of neurodegenerative disorders that exhibit NFTs.

Original languageEnglish (US)
Pages (from-to)1036-1045
Number of pages10
JournalNeurobiology of Disease
Volume8
Issue number6
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neurology

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    Tanemura, K., Akagi, T., Murayama, M., Kikuchi, N., Murayama, O., Hashikawa, T., Yoshiike, Y., Park, J. M., Matsuda, K., Nakao, S., Sun, X., Sato, S., Yamaguchi, H., & Takashima, A. (2001). Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiology of Disease, 8(6), 1036-1045. https://doi.org/10.1006/nbdi.2001.0439