Sibutramine HCl is a new anorectic agent given approvable status by the FDA. It is a potent serotonin and norepinephrine reuptake inhibitor, which reportedly is responsible for the enhancement of satiety and stimulation of brown adipose tissue thermogenesis. Clinical trials have indicated that sibutramine is safe and effective, producing a dose-dependent response in the induction and maintenance of weight loss. In comparison with dexfenfluramine, sibutramine has shown similar efficacy over a 12-week period without any associated pulmonary hypertension. Adverse effects commonly associated with sibutramine include dry mouth, constipation, and insomnia. Effective doses range from 5 to 20 mg per day. Sibutramine appears to be an effective pharmacotherapeutic option for obese individuals in whom diet and behavior modifications alone have not achieved the desired outcome.
|Original language||English (US)|
|Number of pages||15|
|State||Published - Oct 1 1997|
ASJC Scopus subject areas
- Pharmacology (medical)