Focal neuropathy preceding chronic inflammatory demyelinating polyradiculoneuropathy by several years

Ashok Verma, R. Tandan, A. M. Adesina, W. W. Pendlebury, T. J. Fries, Walter G Bradley

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We report three patients who exhibited an unusual clinical course of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in which mononeuropathic limb weakness developed 2, 11 and 23 years, respectively, before the development of generalized polyradiculoneuropathy. The eventual diagnosis remained uncertain until other causes of neuropathy were excluded, and the clinical disorder progressed to involve the other limbs. Focal or regional variants of CIDP suggest that the pathologic, and perhaps the immunologic, abnormalities can be localized and selective for prolonged periods of time. Although this clinical variant seems to account for a small number of CIDP cases, its recognition may aid in making an early diagnosis.

Original languageEnglish
Pages (from-to)516-521
Number of pages6
JournalActa Neurologica Scandinavica
Volume81
Issue number6
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Extremities
Polyradiculoneuropathy
Early Diagnosis

Keywords

  • AIDP
  • CIDP
  • conduction block
  • demyelination
  • mononeuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Focal neuropathy preceding chronic inflammatory demyelinating polyradiculoneuropathy by several years. / Verma, Ashok; Tandan, R.; Adesina, A. M.; Pendlebury, W. W.; Fries, T. J.; Bradley, Walter G.

In: Acta Neurologica Scandinavica, Vol. 81, No. 6, 01.01.1990, p. 516-521.

Research output: Contribution to journalArticle

Verma, Ashok ; Tandan, R. ; Adesina, A. M. ; Pendlebury, W. W. ; Fries, T. J. ; Bradley, Walter G. / Focal neuropathy preceding chronic inflammatory demyelinating polyradiculoneuropathy by several years. In: Acta Neurologica Scandinavica. 1990 ; Vol. 81, No. 6. pp. 516-521.
@article{d6ed131edfc744848a0ef4ae3633efd2,
title = "Focal neuropathy preceding chronic inflammatory demyelinating polyradiculoneuropathy by several years",
abstract = "We report three patients who exhibited an unusual clinical course of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in which mononeuropathic limb weakness developed 2, 11 and 23 years, respectively, before the development of generalized polyradiculoneuropathy. The eventual diagnosis remained uncertain until other causes of neuropathy were excluded, and the clinical disorder progressed to involve the other limbs. Focal or regional variants of CIDP suggest that the pathologic, and perhaps the immunologic, abnormalities can be localized and selective for prolonged periods of time. Although this clinical variant seems to account for a small number of CIDP cases, its recognition may aid in making an early diagnosis.",
keywords = "AIDP, CIDP, conduction block, demyelination, mononeuropathy",
author = "Ashok Verma and R. Tandan and Adesina, {A. M.} and Pendlebury, {W. W.} and Fries, {T. J.} and Bradley, {Walter G}",
year = "1990",
month = "1",
day = "1",
language = "English",
volume = "81",
pages = "516--521",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Focal neuropathy preceding chronic inflammatory demyelinating polyradiculoneuropathy by several years

AU - Verma, Ashok

AU - Tandan, R.

AU - Adesina, A. M.

AU - Pendlebury, W. W.

AU - Fries, T. J.

AU - Bradley, Walter G

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We report three patients who exhibited an unusual clinical course of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in which mononeuropathic limb weakness developed 2, 11 and 23 years, respectively, before the development of generalized polyradiculoneuropathy. The eventual diagnosis remained uncertain until other causes of neuropathy were excluded, and the clinical disorder progressed to involve the other limbs. Focal or regional variants of CIDP suggest that the pathologic, and perhaps the immunologic, abnormalities can be localized and selective for prolonged periods of time. Although this clinical variant seems to account for a small number of CIDP cases, its recognition may aid in making an early diagnosis.

AB - We report three patients who exhibited an unusual clinical course of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in which mononeuropathic limb weakness developed 2, 11 and 23 years, respectively, before the development of generalized polyradiculoneuropathy. The eventual diagnosis remained uncertain until other causes of neuropathy were excluded, and the clinical disorder progressed to involve the other limbs. Focal or regional variants of CIDP suggest that the pathologic, and perhaps the immunologic, abnormalities can be localized and selective for prolonged periods of time. Although this clinical variant seems to account for a small number of CIDP cases, its recognition may aid in making an early diagnosis.

KW - AIDP

KW - CIDP

KW - conduction block

KW - demyelination

KW - mononeuropathy

UR - http://www.scopus.com/inward/record.url?scp=0025353064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025353064&partnerID=8YFLogxK

M3 - Article

C2 - 2171295

AN - SCOPUS:0025353064

VL - 81

SP - 516

EP - 521

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 6

ER -