Focal liver lesions: MR imaging-pathologic correlation

C. Bartolozzi, D. Cioni, F. Donati, R. Lencioni

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Magnetic resonance signal intensity of focal liver lesions is affected by numerous pathologic factors. Lesion histologic features, such as cellularity, vascularity, stromal component, and intratumoral necrosis or hemorrhage, strongly affect T1 and T2 relaxation times. Additionally, intracellular content of certain substances, such as glycogen, fat, melanin, iron, and copper, may also have a substantial role in determining MR signal behavior. In this review we discuss the correlations between MR imaging features and pathologic findings in benign and malignant focal liver lesions. Knowledge of imaging-pathology correlations greatly assist in characterizing focal lesions. Moreover, in certain tumor histotypes, such as hepatocellular carcinoma, careful analysis of lesion signal intensity may help predict the degree of tumor differentiation.

Original languageEnglish (US)
Pages (from-to)1374-1388
Number of pages15
JournalEuropean Radiology
Issue number8
StatePublished - Aug 29 2001


  • Liver
  • Liver neoplasms
  • MR imaging diagnosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Focal liver lesions: MR imaging-pathologic correlation'. Together they form a unique fingerprint.

Cite this