Abstract
In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.
| Original language | English |
|---|---|
| Pages (from-to) | 757-761 |
| Number of pages | 5 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 19 |
| Issue number | 7 |
| State | Published - Dec 1 1999 |
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Keywords
- Cerebral ischemia
- Focal ischemia
- Ischemic preconditioning
- Middle cerebral artery occlusion
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
- Endocrinology, Diabetes and Metabolism
Cite this
Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice. / Stagliano, Nancy E.; Perez-Pinzon, Miguel; Moskowitz, Michael A.; Huang, Paul L.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 19, No. 7, 01.12.1999, p. 757-761.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice
AU - Stagliano, Nancy E.
AU - Perez-Pinzon, Miguel
AU - Moskowitz, Michael A.
AU - Huang, Paul L.
PY - 1999/12/1
Y1 - 1999/12/1
N2 - In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.
AB - In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.
KW - Cerebral ischemia
KW - Focal ischemia
KW - Ischemic preconditioning
KW - Middle cerebral artery occlusion
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UR - http://www.scopus.com/inward/citedby.url?scp=0033502691&partnerID=8YFLogxK
M3 - Article
C2 - 10413030
AN - SCOPUS:0033502691
VL - 19
SP - 757
EP - 761
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 7
ER -