Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice

Nancy E. Stagliano, Miguel A. Pérez-Pinzón, Michael A. Moskowitz, Paul L. Huang

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.

Original languageEnglish (US)
Pages (from-to)757-761
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number7
DOIs
StatePublished - Jan 1 1999

Keywords

  • Cerebral ischemia
  • Focal ischemia
  • Ischemic preconditioning
  • Middle cerebral artery occlusion

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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