Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice

Nancy E. Stagliano, Miguel Perez-Pinzon, Michael A. Moskowitz, Paul L. Huang

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.

Original languageEnglish
Pages (from-to)757-761
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number7
StatePublished - Dec 1 1999

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Ischemic Preconditioning
Middle Cerebral Artery Infarction
Genetically Modified Animals
Ischemia
Research Personnel
Wounds and Injuries

Keywords

  • Cerebral ischemia
  • Focal ischemia
  • Ischemic preconditioning
  • Middle cerebral artery occlusion

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice. / Stagliano, Nancy E.; Perez-Pinzon, Miguel; Moskowitz, Michael A.; Huang, Paul L.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 19, No. 7, 01.12.1999, p. 757-761.

Research output: Contribution to journalArticle

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