Abstract
In a process called ischemic preconditioning, a brief, sublethal ischemic insult protects tissue from subsequent, more severe injury. There have been no reports of rapidly induced ischemic preconditioning. The authors sought to develop a model of cerebral ischemic preconditioning in the mouse that can be applied to transgenic and knockout animals. They found that brief middle cerebral artery (MCA) occlusion only minutes before a severe ischemic insult can induce protection from that insult. Here the investigators describe a mouse model of preconditioning using intraluminal MCA occlusion as both the conditioning and the test stimulus. One or three 5-minute episodes of ischemia given 30 minutes before MCA occlusion for 1 or 24 hours (permanent occlusion) confer significant protection as assessed by infarct volume measurements 24 hours later.
Original language | English (US) |
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Pages (from-to) | 757-761 |
Number of pages | 5 |
Journal | Journal of Cerebral Blood Flow and Metabolism |
Volume | 19 |
Issue number | 7 |
DOIs | |
State | Published - 1999 |
Keywords
- Cerebral ischemia
- Focal ischemia
- Ischemic preconditioning
- Middle cerebral artery occlusion
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
- Endocrinology, Diabetes and Metabolism