Focal ischemic damage is reduced by CPP-ene studies in two animal models.

Ross Bullock, J. McCulloch, D. I. Graham, D. Lowe, M. H. Chen, G. M. Teasdale

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We have studied a new high-affinity competitive N-methyl-D-aspartate antagonist, D-CPP-ene (SDZ-EAA 494), in two models of focal cerebral ischemia. In the cat middle cerebral artery occlusion model (6 hours' survival), pretreatment with D-CPP-ene reduced infarct size by 64% (15 mg/kg dose) and 60% (4.5 mg/kg dose). There was no reduction in infarct size at a dose of 1.5 mg/kg. Treatment 1 hour after the occlusion reduced infarct size slightly, but not significantly. In a new model of subdural hematoma in the rat, the zone of cortical ischemic damage beneath the blood clot was reduced by 54% with D-CPP-ene pretreatment. Neuroprotective efficacy in a gyrencephalic species comparable to that of noncompetitive antagonists thus can be achieved with this agent. These experiments also indicate that competitive N-methyl-D-aspartate antagonists may be clinically useful after traumatic intracranial hematomas.

Original languageEnglish
JournalStroke
Volume21
Issue number11 Suppl
StatePublished - Nov 1 1990
Externally publishedYes

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Animal Models
N-Methylaspartate
Traumatic Intracranial Hemorrhage
Subdural Hematoma
Middle Cerebral Artery Infarction
Brain Ischemia
Cats
Thrombosis
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
SDZ EAA 494

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bullock, R., McCulloch, J., Graham, D. I., Lowe, D., Chen, M. H., & Teasdale, G. M. (1990). Focal ischemic damage is reduced by CPP-ene studies in two animal models. Stroke, 21(11 Suppl).

Focal ischemic damage is reduced by CPP-ene studies in two animal models. / Bullock, Ross; McCulloch, J.; Graham, D. I.; Lowe, D.; Chen, M. H.; Teasdale, G. M.

In: Stroke, Vol. 21, No. 11 Suppl, 01.11.1990.

Research output: Contribution to journalArticle

Bullock, R, McCulloch, J, Graham, DI, Lowe, D, Chen, MH & Teasdale, GM 1990, 'Focal ischemic damage is reduced by CPP-ene studies in two animal models.', Stroke, vol. 21, no. 11 Suppl.
Bullock R, McCulloch J, Graham DI, Lowe D, Chen MH, Teasdale GM. Focal ischemic damage is reduced by CPP-ene studies in two animal models. Stroke. 1990 Nov 1;21(11 Suppl).
Bullock, Ross ; McCulloch, J. ; Graham, D. I. ; Lowe, D. ; Chen, M. H. ; Teasdale, G. M. / Focal ischemic damage is reduced by CPP-ene studies in two animal models. In: Stroke. 1990 ; Vol. 21, No. 11 Suppl.
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