Focal cerebral ischemia in the cat: Pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene

R. Bullock, D. I. Graham, M. H. Chen, D. Lowe, J. McCulloch

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPP-ene; SDZ EAA 494) upon ischemic brain damage have been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of the middle cerebral artery (MCA) and the animals were killed 6 h later. The amount of early ischemic brain damage was assessed in coronal sections at 16 predetermined stereotaxic planes. Pretreatment with D-CPP-ene (15 mg/ kg i.v. followed by continuous infusion at 0.17 mg/kg/min until death), 15 min prior to MCA occlusion, significantly reduced the volume of ischemic brain damage (from 20.6 ± 9.9% of the cerebral hemisphere in vehicle-treated cats to 7.2 ± 4.4% in drug-treated cats; p < 0.01). The competitive NMDA receptor antagonist D-CPP-ene is as effective as noncompetitive NMDA antagonists in reducing the amount of ischemic brain damage in this model of focal cerebral ischemia in a gyrencephalic species.

Original languageEnglish (US)
Pages (from-to)668-674
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume10
Issue number5
DOIs
StatePublished - 1990

Keywords

  • Cerebral ischemia
  • Cerebrovascular disease
  • Glutamate
  • N-methyl-D-aspartate antagonists

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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