Abstract
Background. Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the immunotoxin FN18- CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals. Results. All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients. Conclusions. In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.
Original language | English (US) |
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Pages (from-to) | 1-6 |
Number of pages | 6 |
Journal | Transplantation |
Volume | 63 |
Issue number | 1 |
DOIs | |
State | Published - Jan 15 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Transplantation