FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts

Stuart J. Knechtle, Daniel Vargo, John Fechner, Yuan Zhai, Jue Wang, Michael J. Hanaway, Joshua Scharff, Huaizhong Hu, Leslie Knapp, David Watkins, David M. Neville

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

Background. Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the immunotoxin FN18- CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals. Results. All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients. Conclusions. In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalTransplantation
Volume63
Issue number1
DOIs
StatePublished - Jan 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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    Knechtle, S. J., Vargo, D., Fechner, J., Zhai, Y., Wang, J., Hanaway, M. J., Scharff, J., Hu, H., Knapp, L., Watkins, D., & Neville, D. M. (1997). FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. Transplantation, 63(1), 1-6. https://doi.org/10.1097/00007890-199701150-00002