Abstract
Background. Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the immunotoxin FN18- CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals. Results. All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients. Conclusions. In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Transplantation |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 15 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Transplantation
- Immunology
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FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. / Knechtle, Stuart J.; Vargo, Daniel; Fechner, John; Zhai, Yuan; Wang, Jue; Hanaway, Michael J.; Scharff, Joshua; Hu, Huaizhong; Knapp, Leslie; Watkins, David; Neville, David M.
In: Transplantation, Vol. 63, No. 1, 15.01.1997, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts
AU - Knechtle, Stuart J.
AU - Vargo, Daniel
AU - Fechner, John
AU - Zhai, Yuan
AU - Wang, Jue
AU - Hanaway, Michael J.
AU - Scharff, Joshua
AU - Hu, Huaizhong
AU - Knapp, Leslie
AU - Watkins, David
AU - Neville, David M.
PY - 1997/1/15
Y1 - 1997/1/15
N2 - Background. Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the immunotoxin FN18- CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals. Results. All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients. Conclusions. In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.
AB - Background. Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model. Methods. In order to ablate recipient T cells, the immunotoxin FN18- CRM9 was administered to rhesus monkey recipients of MHC-mismatched renal allografts. Donor lymphocytes were injected intrathymically into some animals. Results. All monkeys with T-cell depletion by immunotoxin had prolonged allograft survival, and tolerance confirmed by skin grafting has been confirmed in five of six long-surviving recipients. Conclusions. In this clinically relevant model, profound but transient T-cell depletion by a single agent substantially promotes tolerance.
UR - http://www.scopus.com/inward/record.url?scp=17044453983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17044453983&partnerID=8YFLogxK
U2 - 10.1097/00007890-199701150-00002
DO - 10.1097/00007890-199701150-00002
M3 - Article
C2 - 9000652
AN - SCOPUS:17044453983
VL - 63
SP - 1
EP - 6
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 1
ER -