Fluoxetine versus placebo in depressed alcoholics: A 1-year follow-up study

Jack R. Cornelius, Ihsan M. Salloum, Roger F. Haskett, Dennis C. Daley, Marie D. Cornelius, Michael E. Thase, James M. Perel

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The authors conducted a first study to evaluate the long-term efficacy of fluoxetine for decreasing the depressive symptoms and the drinking of patients with comorbid major depressive disorder and alcohol dependence. This study consisted of a 1-year naturalistic follow-up of 31 patients who previously had completed a 3-month double-blind, placebo-controlled study of fluoxetine in depressed alcoholics. The fluoxetine group continued to demonstrate less depressive symptoms and less drinking than the placebo group at the 1-year follow-up evaluation. The results of the 1-year follow-up evaluation suggest persistent efficacy for fluoxetine for treating the depressive symptoms and the drinking of depressed alcoholics. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalAddictive Behaviors
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Keywords

  • Alcohol dependence
  • Fluoxetine
  • Follow-up study
  • Major depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

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